Seale oaths eee ar _ oa fo . Exposure to External and Internal Radiation Project Title: 16, . in Vivo Measurement of Radionuclides in Man; Body Burden and Kinetic Factors, Computer Applications RX-O1-01-(b) Technical Progress in FY 1973: (Cont'd.) to the Control Data 6600's, with user access via data terminals, using telephone lines. [It has editing and other file-handling capabilities, i a editing feature has proved to be particularly useful in developing new eae ee Oe oe ey The programs such as the one used for computing x-ray spectra, It is also usful in updating and executing programs that involve periodically adding relatively small amounts of data to a larger set of data that continues to be used. For other jobs that would normally be read in from cards the existence of FOCUS files give the convenience of ready availability without card storage and handling. The output from jobs submitted to the 6600 via FOCUS are usually transmitted via BROOKNET to the Sigma 2 for printout. (Robert son) 17. Expected Results in FY 1974: The clinical trials with synthetic calcitonin will be continued with 18 patients on a low dose level (0.5 U/Kg/3 times per week). The clinical trials involving human growth hormone administration to osteoporotic patients will be continued for one year. Another group of osteoporotic patients will receive long-term therapy with estrogen, androgens or fluoride singly. € ; ~ and in combination. Effective treatment in all these groups of patients should result in an augmentation of their skeletal mass. This will be measured by in vivo neutron activation analyses at intervals during longterm therapy. The effects of physical therapy in mildly osteoporotic women will be evaluated.over a one year period. Studies designed to measure the extent and rate of Joss of calcium in patients receiving long-term therapy with the drug colestipol for hyperlipemia will be instituted, The study of osteopenia resulting from endocrine dysfunction, Thalessemia and Paget's disease will continue. The effects of various therapies will be evaluated in terms of changes in total calcium and potassium. The study of renal osteodystrophy in patients undergoing chronic hemodialysis will be expanded. A number of these patients will be studied The effect of using Ca-47 kinetic techniques while they are on dialysis. in uremic studied be will analogues D -various therapies, principally vitamin to scheduled failure renal with patients, The study, initiated on patients undergp renal transplantation, will be expanded. Geser ications for the in vivo activation technique will be sought. le, changes in body composition resulting from high levels of For @ growth- hormone associated with long-term L-Dopa treatment for parkinsonism will be studied, (Cohn) In the radiation dose response curve studies, an effort will be made to (See Continuation Sheet) bi T9isl