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Exposure to External and Internal Radiation
Project Title:
16,
.
in Vivo Measurement of Radionuclides in Man; Body Burden and
Kinetic Factors, Computer Applications
RX-O1-01-(b)
Technical Progress in FY 1973:
(Cont'd.)
to the Control Data 6600's, with user access via data terminals, using
telephone lines.
[It has editing and other file-handling capabilities,
i
a
editing feature has proved to be particularly useful in developing new
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ey
The
programs such as the one used for computing x-ray spectra,
It is also
usful in updating and executing programs that involve periodically adding
relatively small amounts of data to a larger set of data that continues to
be used. For other jobs that would normally be read in from cards the
existence of FOCUS files give the convenience of ready availability without
card storage and handling.
The output from jobs submitted to the 6600 via
FOCUS are usually transmitted via BROOKNET to the Sigma 2 for printout.
(Robert son)
17.
Expected Results in FY 1974:
The clinical trials with synthetic calcitonin will be continued with
18 patients on a low dose level (0.5 U/Kg/3 times per week).
The clinical
trials involving human growth hormone administration to osteoporotic patients
will be continued for one year. Another group of osteoporotic patients
will receive long-term therapy with estrogen, androgens or fluoride singly.
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~
and in combination.
Effective treatment in all these groups of patients
should result in an augmentation of their skeletal mass. This will be
measured by in vivo neutron activation analyses at intervals during longterm therapy.
The effects of physical therapy in mildly osteoporotic
women will be evaluated.over a one year period.
Studies designed to measure the extent and rate of Joss of calcium in
patients receiving long-term therapy with the drug colestipol for hyperlipemia
will be instituted,
The study of osteopenia resulting from endocrine
dysfunction, Thalessemia and Paget's disease will continue. The effects
of various therapies will be evaluated in terms of changes in total calcium
and potassium.
The study of renal osteodystrophy in patients undergoing chronic
hemodialysis will be expanded. A number of these patients will be studied
The effect of
using Ca-47 kinetic techniques while they are on dialysis.
in uremic
studied
be
will
analogues
D
-various therapies, principally vitamin
to
scheduled
failure
renal
with
patients, The study, initiated on patients
undergp
renal transplantation, will be expanded.
Geser ications for the in vivo activation technique will be sought.
le, changes in body composition resulting from high levels of
For @
growth- hormone associated with long-term L-Dopa treatment for parkinsonism
will be studied,
(Cohn)
In the radiation dose response curve studies, an effort will be made to
(See Continuation Sheet)
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