ium Lung nd. Hyg. termination surements of ent of Radi. mic Energy; 603. APPENDIX C j i "Evaluation g Systemic § - 32, 58 4 MEDICAL FOLLOW-UP OF PATIENT NO. 2 F The ApplicaDeterminat to, rt V. erties of urden in ty in Man y, Vienna, M-704 nium Body mos Sci(April 704 Code ns,” 2 NE ER mapa opes," Brit. heginning in the spring of 1942, patient No. 2 was exposed to uranium halides while attempting to uranium tetrafluoride to the metallic state. reduce Patient No, 2, one of several nonmilitary members of the CUFF group, worked at Los Alamos from February 3, 1944, to August 16, 1944. He subsequently worked at tests including pulmonary function, sputum cytolOgy, tantalum insufflation, bronchoscopy, and lung tomography. Cytological examinations based on sputum, bronchoscopic washings, and brush specimens showed no metaplasia in cells exfoliated from the bronchial tree. There were some indications other installations where he was not exposed to of an inflammatory process which could be compat- raudivactive materials. ible with an underlying bronchial growth. However, late in 1946, he Tomo- was exposed to beryllium oxide and beryllium chlo- graphic tests verified the previous findings of ride. a well demarcated, simple lesion located in the In 1948, he was engaged in hot-pressing ura- nium powder with hardening agents. In 1952, he right lower lung. Fiber-optic bronchoscopy indi- worked with catalytic agents but had no significant cated no abnormal changes in the lung within small exposure to toxte chemicals. bronchioles (to about 3 mm). In 1954, he was exposed to sodium vapors as well as compounds of chlorine, arsenic, and antimony. Very often these Cytological study of specimens obtained by pinch biopsy was also negative. Results of the tantalum insufflation radi- materials were weighed in the open in crucibles ography indicated no intrusion on the bronchial tree that were evacuated and then fired. or deposition defects. The crucibles were opened without the benefit of hoods or dryboxes. In 1960, he worked with cadmium selenite in a vacuum system but probably was not exposed to toxic materials. Since 1965, he has been involved Because of the demonstrable growth of the lesion since 1965, the attending physicians decided to perform a simple lobectomy, and on May 17, 1971, the right lower lobe was removed. Histological sections in the manufacture of electronic instruments used of the tumor and regional lymph nodes were made, and to detect hydrocarbons. samples of the tumor, normal lung, regional lymph During the medical examination in 1966, a nodes, and bone were sent to several laboratories small, coin-sized lesion was noted in the right for radioactive assay and radiographic studies. lower lung. Histologically, the neoplasm was a classical benign A previous chest roentgenogram made in 1960 had been normal. in The follow-up examination 1969 confirmed the lung abnormality which showed no detectable change in size. In a roentgenogram hamartoma (derived from residual embryonic cells) containing considerable adult cartilaginous and epithelial cells. Interestingly, the regional lymph taken fn March 1971, the lesion had nearly doubled nodes were perfectly normal histologically with no in size and then had an outside diameter of about signs of cellular damage despite the relatively high Som, radioactivity. Following consultation between attending Phystcfans, the individual concerned, and staff of the AEC's Division of Biology and Medicine, the Paticnt was admitted on May 4, 1971, to a large hospital in the eastern United States for further diagnostic studies. During the following several davs, he was subjected to a series of diagnosric Patient No. 2 is currently in good health and returned to Los Alamos with other members of the UPPU group for additional study in November 1971. We believe it is worthwhile to point out that there is concern and interest for these subjects even though many years have passed since they worked with 29