2eee0 Thomas d. Haley, Ph.D. the liver is the organ for*éetoxication cf this tyre of amine. Upon the basis of these consideretions it is pcssible to design an experinent which should laed to en elucidation of both the detoxication mechanism involved und the rete at which excretion takes place. Utilizing either or both Tritium (HF) and clad | as in the biosynthesis of epinephrine from recio vhenylelenine, the amphetamine and Gesoxyvephedrine molecules can be tagged on the aliphatic side chain and the unine of the animal collected. ixtraction of the urine according to the ususl methods vould »ive both free and combined amine. Conversion of these extrects to either 2oc*0, (oariun carbonste with ot4) or POW (Tritium hydroxide) would erable the investigetor to cbhicin more accurate deta on the fate and exeretion of these Bephenylisopropyl asins €erivatives. Isolation or the Cagredation preducts “ould entull much greater effort, but both tagging isotepes are sufficiently lone-lived to enarls such en investiCc 2yr. 5B” 0.015 and ott 5100 yr. BT 9.25}. At the time of the developrent of maxinum motor activity mice which nad been Injceted with either dvug could be secritrope and the trains and/or other organs removed. oO de prepared and sectionec and the sections used t These organs could inmake sutoradiographs. This would aid in localizing the exect area in the tissue in which the crug wes contained and in the case of the brain slices aid in determining the exact site of action of these drucs. Another element which has been studied 1s arsenic. . Studies con- cerned with the fate of inorganic arsenic in the body have been cerried out by meny investiszators. been uséd. Both normal and pathological animals have Recently cacodylic ocid containing radio arsenic has become