3eeerhomas J. Haley, Ph.Pp. avatlatle. Jdn04 This organic sarseniesl in general benaves Like the inorganic arsenic compounés, but its excretion rate is much slower. It would be of great clinical velue to study the excretion rate and sites of storage in the boéy of sodium end iron cacodylates beceuse of the large anounts of these compounds used in this country. If they behave es in- org2nic arsenic compounés it vould be expected that they would concen-~ trate in gicbin and acid-ecetone soluble heme freetions of the blood proteins. Further, it ».ould be expected that skeletal muscle would con- tain the greatest smount and that exeretion would take plsce via the Kidneys. v atn It shoulé be pointed cut that the particular animal used in : this typa of ezperirent determines where the greatest concentration of ercenic will be found. sts isve = high blood lezsl concentrated in the b erythocrvtes while in ceneral sll other aninals show Low blood levels, but high levels in the epididymis and liver. Another factor which must be considered is the inode of administration because the oral route results in the excretion of cecody! cxriee, a garlic cdored sas, in expired air, thus inducing an ed@itionsl health hezarec not seen with hypo- @ermic administration. Rudio arsenic (ras?4 16 @ 37 1.3 BY 0.9 0,58) cculd also be applied to the study of the metabolite fate of the organic: arsenicals used in trestment of protozoan infections provided that the experiment was of short duration. Qne compound which would be easily studied is Carbersone (p-carbamidopnenylarsonic acid) because it has proved especielly effective in the cure of intestinal trichohones infections in rats. Such a study uicht shed light on the mechanism of action of this potent anioebicide. A toxicolosicsl study of the formation of ethereal sulfate would be of greet practical importance beceuse this body datoxication nmechaniem