16 FEFECT= bor of Group PE CA hineinacs. . percent of Cipeuzs Tl i Amertean-). ad liede of (iro vy v 'Ttirik). Three peapie ho €rronp Poona one in Group TLeompla ned et tehiyg and cue ¢ of the eves and dicrimuetion These init ae =k and eve symptoms were most Jikely due cor radiation since: Hund viduals who experienced the initial symptoms Jater developed Furthermore the nitiad “ymptomatologs 4 these people was simitar te that reported 1 on stances of accidental laboratory overexposure to radiation, deseribed on Chapter EIT dr a- possible, however, that chemical irritunan os the fallout matermai sheet was predomanan: ts highly alkaline calenim oxule, Wav have ie. centuated the initial vi. ptoms About two-th rds of Group |} were iauseated during the first days upd one-tenth «ome and had diarrhea, ‘One individual oy Crrony IT was nauseated. fi, Groups PT and PV theve were no gastrointestinal (GE) symptoms. lhe information concerning “ymptoms was obtaines by questioning "hrough an imterpreter ba ss eral individuals Despite the repeated interrn gations and the inev:table suggestion of the tie stories remained corsistent AIL GI symptoms sibsided by the thord nas without theraps ind there was ne cecurrer ce The presence. sever ty. aid duration of 1 at sea, Vomiting, and diairrnea ure know? te bent a direct relationship to degree of exposure vn probability of the rerovery CL. 2. Vt mod bos of note that the ineidence of these ~sptom: was correlated with ‘ie dose received and thar there were NO castromitestinal Symptoms 4 Group TV. the largest group, which only l4r cecerse (rl symptomatowgy nay lave cee due to direet ino urv of the @r0 traet as obser. es In animals aftes whole ody irradiation or may have been ron speeic following therapeuth is is 7 ™ absense radiation Various other chnveae conditions which «ere encountered diriug die ourse of opservi can of the exposed groin. were not tae result radiation exposure VP} e cperdenee von ? Node RADIATION eT, exposure ~Hilse 3 Bytes tliscussed below, were similar in groups and it nonexposed imdi- eds 2.4 Clinical Observation and Therapy With Respect to Hematological Findings 141 Clinical Observations and Leukocyte Counts iugqnes tioned radiation induced skin lesions (epilation and conjunetis tis: see Chapter 11! interrogators, \ Berweren [He 33rd and 48rd post-exposure days. LO percent of the individuals in Group I nad in tbsolute granulocyte level of 1000 per The lowest count ob-erved during this period was 100 granulocytes / noic millimeter or below. During this interval the advisability of mr. giving prophylactic antibiotic therapy to granuloeytopenic individuals was carefully con- ~udered. However, prophylactic antibiotic therapy was not instituted for the followmg LALSOND ‘}) AL] :ndividuals were under continuous medical observation so that infection would be tiscevered in its earliest stages. +2) Premature administration of antibiotics nught have obscured medical indications for ‘reatment, and might also have lead to the de- velopment of drug resistant organisms mn inQviduas with a lowered resistance to infecfon 31 There was no accurate knowledge of the cvumber of granuloeytes required by manto prevent infection with this type of granulocyto- nena, Che observed situation was not strictly com- arable to agranulocytosis with an aplastic Harrow as seen following knownlethal doses of iadiition. fn the latter instance, granulocytes tall rapadds) with practieally none in circula- non and ne evidence of granulocyte regeneraion when .nfection occurs (6). In the pres- ent group of individuals exposed to radiation, ost count» reached approximately one-fourth vormai value. but the fall to that level was mitdua and the presence of immature granuwaves an the peripheral blood during the perhe