The fact that D is effectively exposure and not dose also provides into what the basic problem is when one attempts, express the as insight is done in Fig. 1, tv biological respouse of cells in terms of a single variable, i.e., as E, or the proportional parameter D. This is depicted in Fig. 3, the lower panel of which shows conceptually two of the curves given in Fig. lL. In the upper panel is a three-dimensional schematic, on the exposure-No/N, plane of which is depicted the same curve and labeled poiats shown in the lower panel. cell dose distributions, 1.e., On the Ng NpTcelt dose plane are the the relative numbers of cells dosed, as funetion of the cell dose, z. the per las| quar appr tal z ~ cont: o z cénei Teads Rach CELL OOSE z a . i HIGH LET wo iF z 2 = Ps “hit” 1D eo t 1 18 Low LET The \ from r E(ehdeh'O) Fig. 3 A three-dimensional schematic plot, designed to show that any single point on a given conventional absorbed dose-response curve doés not represent a single value of cell dose, Rather, oe each potot, for any quality radiation, represents an entire distribution of cell doses, as shown on the plane representing Ng/Ne VS Z. - heac” , these j inveate Substir QOn-ana idea of Feinend 8Pplieat Stochas, recent ( 2G 14