5. Cerebelluna, Lefts Too meninges are delicate, They contain occasional srall round calls, A coderate nunter of Purkinje cello have disap- peared. A fow Purkinje cella take on a diffusa blue in crosyl~ viol: t-stalned sections. A few glia in the moleoular Zone con~ tain spurse blus-groen lipid granules. The nerve cells of the dontate nucleus shew marked lipofuscin plementation, and in the glia there are fairly prominent blue-green lipid droplots., Hydropic enelling of oligodondroglia is present, but it ie less 4, . conspicuous than in the white matter of the cerebrus, Nerve cells of the dentate nucleus hava probably suffered a reduction, 6. The meninges are slightly thickened. Nerve cell pcpulation appears nor.al. Ina the antcrior horn cells, lipochrose deposits are proainent., No alterations arc seen in the spinal roots, i There 1s no evidence of de,enorative change, i Bot ep ET Spinal Cord, Thoracis: ‘ -~ but there fs no glial proliferation, +> wares en a a tame mrryermece scm een tere ». 7. Sumuary ena Vonients e The meningeal arterioloeclcrosis is oderate aud not unexpected in a min of this ale (40 y<ars), No ex»laation for tha ycllow meninges! tint deseritcd at autoosy, i.as found. The chromatolyuis anil pyknosis of occasional nerve cells :.zy te as@ erited to conditicas related to the agonal state or they may rep- resciut a petteasrtyn chance. the lipofuscin pignent in o-rve cells, most proneunced in tha dentate nucleus of the ccrebellun, is regarded as in the usual range at this ago level. Tha pigmentory chan ves in the glia, especiailyastrocytes (most marked in the ceretral cortex), probably repreeent physiological invelutionarychanges. In this con ection, Penfield (1932) has stated that "pigwent granules appear in astrocytes cepzecially in older’ subjects. They are avidently the result of cell degencration rather than ingestion,” and Mic-Korteg: has stated of microglia that "in saze cells sthere are Lipoid pranulations.*® It is possible that the iavolutionary chance is more pronounced than usual. wa hydropie ewelling of the oligodendroplia, nost prominent in the czrebral uhita matter, is a nonspecific altaration found in a variety of corditions, e.g., casa and early wdeza, It has been found in experk.ental animals (monkeys) under nora2l con- 3 HAIVES -US DOF ARC | | . sdatpibei Shs eet ditions, in which the brain has teen fixed 3 hours post rorten,