only
tne
risk that a cell will
be dused ama
that ‘use will be of a glven
size, but also, with the HSEF, the probibilLq@ that that dose will cesuic
Lu a quantal response.
metec’,
cather
Now
thac
Thus
Ule shantun snould be called a “cell
than just a cell
tne basic outlines of
Nnecessacy more detailed
risa
pnanton.
the anproaaucn tave been
trtorcnaciun on eacn elerwnt of
laid out,
tne
the uverill aporoac:
can be provided.
Organ Dose:
In order
first
to explain anc extend
co demonstrate
organ and
that
Conceptual Exposure
the
the above statements,
it is useful
relationsulp Setween the absorbed dose
to "he c#llularc elements of
the system.
to the
This can be Jone as
follows:
/
z
j{[la
D=
‘
~
N
/
Zy 777}
zZ,
“lb —/ = fia
+
”
E
+
~
)
Zz, 77>
“Ib
5.
‘J
the celi,
i-e.,
H
hic ana exposed cells,
the
“cell cose";
vespectively,
a ceili TCV receiving an energy ceposto
Lye
to
-.
-2?,,
is
(1)
ba
target~containing volune
the mundec of
the staple probabilirey of
iuctny, eapusure ©, eGual nutecicalc-
tides
However,
in which 4 ts
it is
«ell known
"fou poysies
energy~conveying charged
fluence
"cross
Eq.
to which the
section",
GL),
that,
ths. £Eteld strength weasured as fluence cate (units of
particles cem72 cnt), which express
from Eq.
or
particles;
tccal exposure
constant
of
the
rate of exposure (of cells) to
tr is
the exposure
Thus,
=a
24,7 =
Clie;
{is numerically equal; and
proportionality.
(2),
D =
5007459
[F
=
‘., and Ne are
and ry
i
N
fn whtch 2 £3 a single energy deposicticn in the
(TCY) of
“
Kf “os
Kk"
is
the
the
c—- ts
subscituting
Chie
tn