Henatopoiztic Molecular Revulaturs in the janasement of the Lone Marrow hypoplasia In the have been last ten years identified, techniques are several rolecular regulaters of hes purified, being produced erythropolein. macrophages, and by recombinant wv... in large amounts. and 3, granulocyte~ macrophage colony-stinulating f2etor, sequenced, These are interleukin-- c-lony-stinulating factor, macrophage aranuleocyte colonmy-stimuiating Cuctur, and Interleukin-l, a ;roduct primarily of activated monocyte sti-ulates T-cells, endstsealial celis, and fiorobliusts produce granulocyte-macrophage colony- stinmlating tactur. accelerates potesis the production of granulocytes and macrophages The or to latter in vitro and upon in’ vivo administration produces a 3ranulocytosis with accelerated production of granulocytes. functional granulocytes It aiso increases the effectiveness of the in phagocytosis and tacterial killing. colony-stinulating factor accelerates Granulocyte in virro the production of xranulocytes in colonies and in vivo accelerates the procuction of granulocytes 3nd improves (55-55). [IL-l has hours prior in to the mouse the ghe socytic ang been used as a irradiation, IL-1 radioprotector. to near 100% survival. £6 4-5 tines has been given mo ww et erec timates ang shoun the noraal level as When administered four hours tefore oc to produce a susteines granulocyvtssis of (51-54). louzg as GM-CSF aud G-Cs: the materials are administerec. to prinates and mice in which by raciation or chemicals and when acwinisteces 26 turns a near 100% lethal dose of radiation 45 hours before, it is ineffective (50). atmladr cacterial-silling capaitle It the marrow uas been stopressea the granulocyte cuunts are increased Erythropoietin has been shown tc te of sajor benefit stimulating tae peoauction of reu cells in as a result of renal failure (55). It is assumed that combinations will be of potential tenetit with bone marrow suppression as a other hand, individuals with in tne treatrent of result of whole boay individuals irradiation. Ga the it is concelvable that forcing cells into mitosis before LNA is adequately repaiced may fix genetic injury and result in either an early failure of increased the mitotic capacity of pluripotent stem cells or an earlier incidence of leukemia. ‘These are possibilities explorac experimentally. 1? 500 1u98 ana that aeed to bu