Henatopoiztic Molecular Revulaturs in the janasement of
the Lone
Marrow hypoplasia
In
the
have been
last ten years
identified,
techniques are
several rolecular regulaters of hes
purified,
being produced
erythropolein.
macrophages,
and by recombinant wv...
in large amounts.
and 3, granulocyte~ macrophage
colony-stinulating f2etor,
sequenced,
These are interleukin--
c-lony-stinulating factor, macrophage
aranuleocyte colonmy-stimuiating Cuctur, and
Interleukin-l, a ;roduct primarily of activated monocyte
sti-ulates T-cells,
endstsealial
celis, and fiorobliusts
produce granulocyte-macrophage colony- stinmlating tactur.
accelerates
potesis
the production of granulocytes and macrophages
The
or
to
latter
in vitro and
upon in’ vivo administration produces a 3ranulocytosis with accelerated
production of granulocytes.
functional granulocytes
It aiso increases the effectiveness of the
in phagocytosis and tacterial killing.
colony-stinulating factor accelerates
Granulocyte
in virro the production of
xranulocytes
in colonies and in vivo accelerates the procuction of
granulocytes
3nd improves
(55-55).
[IL-l has
hours prior
in
to
the mouse
the ghe socytic ang
been used as a
irradiation,
IL-1
radioprotector.
to near 100% survival.
£6
4-5
tines
has
been given
mo
ww
et
erec
timates ang shoun
the noraal level as
When administered four hours
tefore
oc
to produce a susteines granulocyvtssis
of
(51-54).
louzg as
GM-CSF aud G-Cs:
the materials are administerec.
to prinates and mice in which
by raciation or chemicals and
when acwinisteces 26
turns a near 100% lethal dose of radiation
45 hours before, it is ineffective (50).
atmladr
cacterial-silling capaitle
It
the marrow uas been stopressea
the granulocyte cuunts are
increased
Erythropoietin has been shown tc te of sajor benefit
stimulating
tae peoauction of
reu cells in
as a result of renal failure (55).
It is assumed that
combinations will be of potential tenetit
with bone marrow suppression as a
other hand,
individuals with
in
tne treatrent of
result of whole boay
individuals
irradiation.
Ga
the
it is concelvable that forcing cells into mitosis before LNA is
adequately repaiced may fix genetic injury and result in either an early
failure of
increased
the mitotic capacity of pluripotent stem cells or an earlier
incidence of
leukemia.
‘These are possibilities
explorac experimentally.
1?
500 1u98
ana
that aeed to bu