/ / / iol Ae Objective: ‘7. ° Teast for J ~- Division, LiL The funiansntal objective of the biological program is to provide information which can be used in planning effective madical care for the victimes of atomic warfare, ami for the vicotins of iniustrial scsctdents in nuclear enercy plants. Such planning must nmecesanrily depend on radiobdiclocical stucties which utiliae the unfius radiation of the atomie exploa fom. A satisfactory Dialogical test procran should provide data which can permit eveluntion of atom bomb r-diation injury in terms of the injurious action of roontgen, garma ani neutron redfationa of ea character that cen be produced by conventional means in the laboratory, Adequate medical Dlaming ean not be anticipated util it fs possible to trans late laboratory comiitions to field conditions with a high degree of certainty, B. Programivhich has been approved by the Division of Bialocy and :ied= . 1.0 icine, Atente Snergy Comiasion, and J-Division, Los Alamos Sefentifie Laboratory: Gol This project will provide an sdequate mmber of or uso at ahot timo. These animals wild have been born and seared on Japtan islani, ani should thon be acclimatized to to the total local enviroment. suitable control studies will be performed prios to the shots, The response of the animls will be tested with 250 KV xray after residence in the tropics, The plan shoulaé provide the following nubers of animals for the testa: 12,000 mice of IAM, strain; 120 Anerican for terrtpp dogs; and 180 Durco *hairless* pics. “ 2.0 acute fation in Theas studies will form a basis OF a ecmperiaon iologieal response to short~-buraet reiieation from the atom bob with the response to ionizing radiation delivered at conventional rates. 2.1 Stuty of acute lethality, Liky, ant survivial versus dose am distance, (all species) 22 Study of histologte changes in tiasues obtained by serial sacrifice after exposure. (all species} 2,5 Stady of histochemical shanges in tissuos, as in 2.2. 2e% Stuly of chan:es in enzyme systems in tiasues, as in 2,2 2,5 Study of protective agents on LDeyj. (mice) 2e6 Stuty of effect of atom bomb radiation on longevity and caroinogensis in survivors. (mice) elie, #l-