> - 4: . 33 is essentially a review of his analysis, , which has become known as the "Geesaman hypothesis." A The Geesaman Dr. Roy E. Hvoothesis Albert and co-workers performed a number of experiments on the induction of cancer in rat skin?47 36, Albert's study of radiation-induced carcinoma in rat skin gives some quantitative description of a high-dose carcinogenic situation. A skin area of 24 cm? was exposed to electron radiation with various depths of maximum penetration. The dose response curves are reproduced in Figure l. In all cases the response at sufficiently high doses 3000 rem) exposure. was (1000- large, 1-5 tumors per rat by 80 weeks post It was noted by Albert that when the dose was normalized to a skin depth of 0.27 milimeters, the three response curves became continuous (See Figure 2). 33/ Geesaman, D.P., UCRL-50387 Addendum, Op. 34/ Albert, R.E., F.J. Burns, and R.D. Since this cit. Heimbach, "The effect of penetration depth of electron radiation on skin tumor formation in the rat," Radiation Res. 30, 1967, pp. 515-524. 35/ Albert, R.E., F.J. Burns, and R.D. Heimbach, "Skin damage j and tunor formation from grid and sieve patterns of electron and beta radiation in the rat,” Radiation Res. 30, 1967, pp. neon ae 36/ Albert, R.E., F.J. Burns, and R.D. Heimbach, "The association between chronic radiation damage of the hair follicles and tumor formation in the rat," 1967, pp. 590-599, re oe ~ : ow ” 7 aa . WR ee, “oo Matty hey = bye “ wt: wpe they ea PP EY wae oe, - , . vo SR re wT de x . \ . a “—F 7 Radiation Res. . pt a OT ‘ , geet ee peat : ir ia: vt Myo w t a Mwae wit. we gra: Ny Mae - waned a, t st “date: a a we eg a aleagh an Reaedee rn a a ODAB QR Bp ate de is ” fi, Ley vlad ~ . é toy bet : 30, 4 ' i | “* e ty eo » r ‘Puta nO oe oe 46