>
-
4:
.
33
is essentially a review of his analysis,
,
which has become
known as the "Geesaman hypothesis."
A
The
Geesaman
Dr. Roy E.
Hvoothesis
Albert and co-workers performed a number of
experiments on the induction of cancer in rat skin?47 36,
Albert's study of radiation-induced carcinoma in rat skin
gives some quantitative description of a high-dose carcinogenic situation.
A skin area of 24
cm? was exposed
to electron radiation with various depths of maximum penetration.
The dose response curves are reproduced in Figure l.
In all cases the response at sufficiently high doses
3000 rem)
exposure.
was
(1000-
large, 1-5 tumors per rat by 80 weeks post
It was noted by Albert that when the dose was
normalized to a skin depth of 0.27 milimeters, the three
response curves became continuous
(See Figure 2).
33/
Geesaman, D.P., UCRL-50387 Addendum, Op.
34/
Albert,
R.E.,
F.J.
Burns,
and R.D.
Since this
cit.
Heimbach,
"The
effect of penetration depth of electron radiation on skin
tumor formation in the rat," Radiation Res. 30, 1967, pp. 515-524.
35/ Albert, R.E., F.J. Burns, and R.D. Heimbach, "Skin damage
j
and tunor formation from grid and sieve patterns of electron
and beta radiation in the rat,” Radiation Res. 30, 1967, pp. neon ae
36/
Albert,
R.E.,
F.J.
Burns,
and R.D.
Heimbach,
"The
association between chronic radiation damage of the hair
follicles and tumor formation in the rat,"
1967, pp. 590-599,
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