pT a
.
NATIONAL INSTITUTES OF HEALTH
CLINICAL STA
Several points of interest are revealed by
these data. The two subjects with severe
growth retardation (Cases 3 and 5) had very
low thyroxine iodine levels, little or no
accumulation of 3871 by the thyroid, and
very high levels of TSH in blood. The
TABLE 9.
Case
Sex
Thyroid
*
roe
Internal aN
latterfinding indicates that the growth retardation was due to primary thyroid failure and not to pituitary failure, which was
suspected before the appearance of clear-cut
thyroid findings. Several of the patients
who had had partial thyroidectomy (Cases
Thyroid Studies in Subjects with Thyroid Abnormality*
Abnormality
Age
Year
Tested
vr
3
M
Atraphy
13
5
M
Atrophy
13
17
F
15
21
F
69
r
2
M
20
M
Nodular
goiter
Nodular
goiter
Nodular
goiter
Nodular
goiter
Nodular
Neck “I Each 4 Hrf
Pre. TSH
PostTSH
% of dose
Serum Iodine
PBI
Tal
mye ol
1.4
3.2
1.9
3.1
6.8
18
8.1
1.3
7.1
5.7
7.9
§.2
6.5
0.8
1.0
0.8
1.8
> £20
159
119
248
<0.5
372
<0.5
440
19
18
1965
15
1966
(15)
(24)
5.7
4.6
20
1966
12} (16)
(24)
7.9
4.9
13
1965
1966
1966§
19
8.3
5.0
3.9
4.3
3.3
15
16
13
8
6.5
(29)
18
(31)
(23)
(31)
TSH}
we/ 100 ml
1965
1966
1965
1966
1964
1966§
1964
1966§
1965§
1966§
1965
1966§
1965
5
Serum
17
4.2
2.6
4.2
125
9.6
26.6
goiter
72
F
42
F
61
F
54
M
19
M
36
M
33
F
65
KF
59
I
40
M
o4
i
Nodular
goiter
Nodular
goiter
Nodular
goiter
Nodular '
goiter
Nodular
goiter
Nodular
goiter
Nodular
goiter
Nodular
goiter
Solitary
nodule
Solitary
nodule
Carcinoma
17
19
_
35
4
1965
13
13
at
5.3
»
1965
1966
1965
1966
1965
1966
1965
1966
1965
_—
1234
4.1
(16)
.
(24)
17 (9)
(14)
7{| (20)
(19)
1966§
(38)
{28)
4.2
7.0
5.9
4.9
3.1
8.2
8.6
10.3
4.3
3.8
2.1
1.9
5.3
<17
<3
<17
<17
<17
7.3
197
6.4
23.5
4.8
8.6
3.4
49
2.0
* TSH = thyroid-stimulating hormone, PRI = protein-bound iodine, Ta] = thyroxine iodine.
t Values in parentheses are ‘‘corrected!’’ counts obtained at Brookhaven National Laboratory (see text). The
others are not corrected for extrathyroid counts.
t Assays in 1965 could not detect levels below 3 mug/ml. Seven unexposed children in the same age group had
<3 mug/ml. Assavs in 1966 could not detect levels below 17 mug/ml. Three exposed children without thyroid disease
(Cases 6, 8, 32) had <17 mug/ml. Two children exposed in utero (Cases 84, 86) and two unexposed children had
|| While taking thyroxine.
ww
§ After partial thyroidectomy (for Case 64, total thyroidectomy).
en foe ie
<17 myg/mi.