- J « Ray Radiation Effect on the Thyroid As part of our interest in radiation effects on the thyroid we h most completed a follow-up study of a selected group of patients wh fore 1950 received x-ray radiation to the neck which presumably incjuded @ thyroid area. All of these individuals were given x-ray therapy for berculous cervical lymphadenitis. Most of them were children or yo ults when treated. Of almost 200 patients so treated, 66 have been aced and brought back for our personal examination of the thyroid. elve of these were found to have at least one discrete mass nn the ght have submitted to surgical removal of the mass. There were two th follicular adenomas. Of 60 additional individuals knot.n to have died, e records of post mortem examinations are available on 46. Two had sions of the thyroid; one of these was a carcinoma. Most of the patients o died did so within S years after the radiation therapy had been ur patients who have very discrete firm masses, but refuse operation, ise considerable concern to us. A final effort will be made once induce these patients to submit to surgery. eted soon. The study should be c ferences: Maloof, F., Dobyns, B.M., and Vickery, A. L.: The effects of varibus doses of radioactive iodine on the function and structure of the thyroid of the rat. Endocrinol. 30: 612-638, ).952. Dobyne, B. M., Vickery, A. L., Maloor, r., and Chapman, E.M.: and histologic effects of therapeutic doses of radioactive icdine thyroid of man. J. Clin. Endocrincl. & Metab. 13: the 548-567, 1953. Dobyns, B.M., and Didtschenko, I.: Nuclear changes in thyroidal epithelium following radiation from radioiodine. & Metab, 21: 699-720, 1961. J. Clin. Endocripol. Dobyns, B.M., Rudd, A.E., and Sanders, M.A.: DNA synthesis in the radiated and stimulated thyroid (Submitted to Endocrinol.) Macintyre, M. N., and Dobyns, B. M.: Anomalies in chromosomes of the circulating leukocytes in man following large doses of radioactive iodine. J. Clin. Endocrinol. & Metab. 22: 1171-1181, 1962. LEGAL NOTICE sme,marthentann,boro) PatonrteeeCa” Sune A. Makes any war?i:ty of representation, expressed of implied, ith reepdlt io the arceracy. completeness, ¢4 coafuinens of the information contained te this report, ie thet the wae of my Information, apparatus, muted. of process diecleced in privesely owned rights; or tate feport not tndringe ng from oe =F ome o exiet than er premres, OF provides occeus ts, any taformation parveand te his employmalt or cowlfect