106 LARSENetal. TABLE Ii. PRIOR EVIDENCE OF THYROID HYPOFUNCTION AND CALCULATED THYROID EXPOSURE Description Subject identification Thyroid estimated dose number (rads) 1. Two subjects with frank hypothyroidism ~ 10 years after exposure 3 5 2. Five subjects with hypothyroidism or decreased thyroid reserve pre-operatively 2 20 810-1150 810-1150 3, Three subjects with impaired thyroid function following subtotal thyroidectomy 1150 1150 33 810-1150 42 810-1150 65 810-1150 17 810-1150 21 810-1150 69 810-1150 TABLE III. RESULTS OF TSH STIMULATIONTESTS IN EXPOSED RONGELAP SUBJECTS AND CONTROLS Mean + SD Mean serum Ty prior to TSH (10 U 1M) (ug/dl) Mean serum Ty, increment 24 h after TSH (ug/dl) Controls 6.0 £ 1.7 4.2+1.3 Exposed Rongelapese (n = 26) 6.6 + 1.7 2.441.2 METHODS Studies were performed during the annual or semi-annual visits of the Brookhaven medical team to the Marshall Islands. Subjects were instructed to discontinue thyroid medication for two months before the studies of thyroid