HPMAN AD. 6.5 Radiation Syndromes as a Func- 6.51 Effects of Superficial Penetrating and In- tion of Tvpe of Exposure, Dose and Time After Exposure ternal Radiat.ons Radiation injuries car be caviced onte turee veneral classes: at. The syndromes of whole body radiatien injury which are produced bx penetrating jen lazing radiation, and which ure dose dependert b. Superticial radiition turns produce soft radiations (bets anc vamma radiations) ce. Radiation injur 1 iow oneregy Noon procuced oy the depos; tion of radionuclides wittir che body Te clinical pieture varies with the site and amount of deposition. Each of the above s assectited witha earls phase in which acute symyprom- ond sens mas be observed. and a date phase ii vhich onron i changes or manifestations such os caneer mi be observed. Also, tue deyree of aajury + pre portioned to dose. Part cmiarh) ia Class oa. total-body irradiation, the dsease ennity see is highly dependent om 6.52 oo + The Syndromes From trating Radiarions [otal Body Pene The dose-dependent naromes vesulti g from total-body exposure he onaniinad sieve been deseribed in detuie 13. ang reed ot ys be summarized here \fter darge doses proximately 6,000 rarinot * ous system synd rover ap the eentene nee e Ns So prodin ed (10). Death may occur aader tae beam after some hours, and is orecenec ha tiypereser a bility, ataxia. respi ulory tistress. aud ter mittent stupor. Doses caoanle of jroduecr y this syndrome are always an formix fata. Uf an occasional amimun sary TON oo topeua and depressed defenses against In- fection, thrombopenia, and anemia with the pos~ tie vesultines mfeetions, diffuse purpura, and yEoxa due to anemia, any of which may be fat More detailed deseriptions of the pathogeiesis «f these phenomena have been pub[sted tte Tey Phe vbexse pieture of radiation syndromes is Pased oon apimad experimentation: however, Upuin exper ence 16, 17-22) has indicated that mat oeobabl. corresponds quite closely to the werent ma din response outlined above Hoothe exception of some differences in time fowearrenee. The CNS apparently was not peeved oy the Japanese ot Pireshima and Maorasaki taeey fey aden es larcoa ty us ore deaths from the HS «6, 18, low dowever, in the case of man, deaths fea ofeetion were most prevalent in the vd Poth weeks omasimuam imerdence darme 3d web ine from hemorrhagic phenomena mn the nooo sth weeks CmaNXinsim iedence im 4th week To toe -Fipanese, after the bombing of Tbooshine aod Nagasaki, deaths from radiaoe HN Vere ma eaths hythoge *Species Virbac adi of. 24 nor would one expect it to fe onserved since doses to produce this synreme vere well within the aren of total de-feontoon Vhe trIS with slenths im the ist beth ore vel documented clinically and patho- oe ths ONS he os Poe 101 ,okecess of SoG pas always fatal withm 3-9 dive ** “The GIs is so named because of the loatred iaisea, vomiting. diarrhea, and denurato oof The smail bowel mucosa. The GIS is to afermiy tatal <vyndrome in most laboratory voowos Pf the short duration GIS of a few mars foes not produce the 5-4 day death, the -u overs of his syndrome have vet to experisys tue sequelae of bone marrow depression whoo, liu been termed the Aemopotetie synteens (HS) The THiS as not necessarily fatal. [os the chien pieture that is seen in the etral eange for all mammals and in general qe dda values reported represent the LD), for hoe sequed of hernopoletic depression—granu- vet toexpertence the pacts atest wal sundries (GIS). LO) 12) whee wn Ny fs ore vere occurring is diate as the 7th speeres and strain varrations pre dest arevclert ap ooo Oth daivs are seen ee Phe 3-4 dogs. cats adb mice, Gonmen pugs and