HEMATOLGeTe
at doses well belowthe lethin range. and ineren--
ing dose resuit< mn one or donna
farther ae.
crease in count
Lavmphocvte sepresston ay
pears to have no caused reloonsthip wath aense
radiation deaths.
¢) Platelet counts iave veer -tudied most
extensively in dogs (26)
Y wath neutroplhiles,
the rapidity and maguitude of depression = 4
function of dose below the letha: ringe
Viax
mum depression oceurs by fe Sth or both chis
with doses in the high letha. cenge. by che loth
to 15th day at subletual level). Recovery begins during the 3d week. bur is not complete fv
the 380th day when most stu es live been term:
nated. Insufficient dita us available to ond
cate the time required
for
1
the mouse using spleri fomogenates, induced
bacterial infections ard spoutaneous Infectious
have indicated that curgea
neutrophile levels
is correlated with
the absolute neutrophile count following whore
body irradiation (15)
59
“oo, and essentiilly the same calculated exposste bar for which control hematological
as were considerably different (the Lympho\te
count ts pot sutable for comparison since
degree
of dlepression was essentially the same
Po vouese ereups and the higher-dose Rongelap
ETO p
At the time of penk depression for
euc! orferment. the neutrophile counts were
esse iialiy identient in terms of absolute counts,
boat
ooisnmlerably different in terms of the re-
4a
Approximation of Minimal Lethal Dose for
Man
sper ove eoutrol values
Thus, some evidence
oi forded that) ipsolute counts. rather than
eurt> relative to control values, may be the
wer sehaole index of exposure in this dose
omplete recover,
Considerable evidence ua. cluding studies
exist. below which sueviva
BSEP AA LIONS
From data an dogs.
t
appears that surviva, is linels uiiess meutr
phile counts remain below Pvc cells for 4
period of time.
Platelet data on devs neaeate that animals
with external purpuri nat. pdatelet counts of
soe
oncheation of severity of exposure can
be viene freni a comparison of minimum inav dat, counts in fapanese groups in which fataltes occurred
In general, a significant
hoinber
dv
ft deaths was encountered only in in-
dandy
nin
vhose neutroplule count fell below
dn) Group 1. #2 or approximately 50 per-
cent cad neutrophile counts below 2000 at some
us
tating the observation period, and 10
weroens had counts below 1000, By this ert
terror thea. the etfective dose received by the
platelet counts asa fuietion at dose rn the sa:
lethal range. The response if te olatelet cout
du
epproxiuately an additional 60 to 100 r
cee ceriuired to lower the nentrophile count by
50,000 or below
Sufficient data oon
arge on minus ure not
vet available te quanafs tie extent rf as
mum depression of © ther “he nentrophile or
in the present study aa. or uch less subject
fluctuation than were tae
eurronhile or lyr
phocyte counts
preceeding
For
' e
o
rerser s,
systematic investigaten «ot che platelet oud
leukocyte counts in ticee a mats toa funericn
of dose in the subleth orate are imdicated
It Is not possible t+ sas it present whether
severity of exposure, or of radiation diame
correlates better with ubsol te levels ef pernpit
eral blood count. or
from
control
woth
dearee
or pre-expesuse
of ethane
evel
Sore
evidence on thes pout con pe aa ned by cara
paring the degree of depre stor ef the mente
phile counts 1 Crror ps |
nel PTE enh
of
Korvelap oeoole iupproached the lethal range.
Poche cdoe
hoes
aim
Cronkite and Bond, unpublished
in the high sublethal close range.
broese ditt enn oe applied to man, an addi-
met
© tf Liter would have placed the dose
veo
tte Jethal range. On the other hane.
powecer or is eclenr from the presence data and
Sores
ontealy xperence with therapeutic ridia-
or om eatropatle counts between P00: and
Phe
Gaan betes are in genernl well tolerLoe
fhumat bemgs with these levels of nenGed
tes
show
one chiniea,
evidence of
ness,
ve cateady actives and generally doe not need
eon tietie Gafrprotie therapy,
Por peo de of Crronp Pare estimated to have
soe
Ter ois
thenheted from: dose rate read-