which
the
cell
population of an Oryan vr other cell population of interest
is exposed,
5
ure
warbed
CHROMATIO EXCHANGES PER 100 CELLS
aor
its
rication
FOr
M+ RAYS
HELM
LUTHiUM - Se MEW
LITHIUM - 30 MEV
SORON
|
’
|
CARBON
6c}
af
&
v/
Lr
Y ov
a
Oe
%
OXYGEN
a
2
~5
a
SOF
40;
30F
20+
700
de tailed
200
300
400
DOSE IN RAD (3x, FOR HITS CELL: X-RAY ONLY)
ily te
Fis. 1
me
sently
Conventional absorbed dose-cell quantal response
functions for radiations of a wide range of qualities
{from Ref, 2).
It is indicated on the abscissa that
the absorbed dose, in cellular terms, translates with
LLE, into number of hits/cell (the numerical value given
for hits per cell, which changes with radiation quality,
is
for x-rays only).
replaced
Thus the basic problem appears to be conceptually identical to that
encountered by the early physicians who wished to know the dose to the
organ.
The radiotbiologist concerned with the study of single cell-
intttated effects must be
interested in the number of cells dosed at all
and in amount of energy deposited in the individual cells--not with
physical quantities
to what may be
in
the environment of
cells.
The solution
to this problem must lie in the same approach used by the
physicians, who had no direct way of determining
the dose that the
tumor or normal tissues were receiving from a piveu exposure.
Say,
since the requirement is
to estimate
the doses
to
characteristics of a “cell phantom” must be outlined.
Living
That
living cells,
However,
is
to
the
in dotiag so
one must keep in mind that, unlike the early (aud present) physicians who
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5012964
i
enee
the
that relate only