the fraction of hit cells responding quantally at each cell dose point on
the distribution obtained with LLE only, are shown as
at
in
distributions within
the larger ones.
distributions yleldas
the
quantally,
for each of
The area under each of
the smaller
total fraction of exposed cells responding
the expusures marked E-1,
E-2, and E-3.
It is
this
fraction, of exposed cells responding quautally for a given amount of
exposure,
that is
actual result
In
the end product of
the
risk evaluation.
the given cellular system, i.e.,
[It
the excess
is
the
total
incidence,
that system, of transformed cells resulting from the given exposure.
a value can be obtained in this manoer for any amount of exposure
in
Such
to a
radiation of any LET, or mixture, without any requirement to utillze the
“Linear, non-threshold” function required in the currently used approach,
However,
it may he useful
to show how the proposed approach can be
tied into, but differs from the present system.
Fig. &
This {is illustrated in
The linear curve in the left hand panel permits one to determine
the number of hit cells, or the risk of a cell oeing hit, for a given
PT
{
t
|?
|
|
|
wl
¢=]
|
|j
|
|
or
|
&
*;
fo
lq
rd
~
|
|{
|
!
tions.
HSEF
*
|
|
DienE)
j#
ne
3
2
| AREA# Iq
Le a
Fig. 6 Schematic plot showing the use of a normalized z
distribution. Multiplication of this distribution by the
nit size 16°
HSEF permits one to estimate the fraction of cells
responding quantally (solid circle on the curve marked
T, in the left panel), from the fraction of cells hit
and dosed (open circle on the curve marked F),
.
a
+
.
2 product6s —
-217-
Bea's
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ta
the much Staller
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