EFFECTS OF IOWEBING RABLATION
2
Pykwesis of cells of the basal layer waa com-
monly seen.
Fora! disorganization of the
im some casea. No damage to fibrocytes or collagen fibers was noted.
malpighian and basal layers was usually preeent in the more extensively damaged arcades
(Plate 23). Cells laden with pigment were
frequently present throughost the epidermis
powure. Epidermis. In general, reperstive
processes of the epidermis ha| p. uceeded, except
tian with parakeratosis was visible in all see-
growths of the stratum malpighii (Plate 27).
These changes occurred in areas of the greatest
and intercellular pigment was noted in some
sections. The stratus: granulosum was usually
atrophic or even absent. Imperfect keratinisza-
tions. The stratum corneum was loosely fibril-
lated and hyperkeratotic.
The arcades of minimal damage were usually
found in areas where sweat ducts approached
the epidermis (Plate 22). There was an apparent increase in the number of cells and mi-
totic figures along the neck of the ducts and
the adjoining areas where regeneiition was
underway. In theses areas the stratum granu-
losum appeared almost norma! in width.
In
contrast to the more severely damaged areas
where pigment was increased, these areas of
minimal damage showed an actual decrease,
heing almost free of pigment.
Dermis. Changes in the dermis were confined largely to the pars papillaris and superficial pars reticularis (Plates 21-24). Mild
edema in some cases were noted. Capillary
loops were often indistinct and when discernible they frequently were associated with an
increased number of pericytes. The endothelial cells showed swelling and were polygo-
nal in shape.
Telangiectatic changes were
noted in these areas where the overlying epiderniis showed yreatest damage which were
associated with perivascular lymphocytic infiltration. Chromatophores, filled with mela-
fin were prominent in the superticial dermis.
The fine elastic fibrils running tnto the pars papillarix were often altered or absent.
Little if any damage was seen below the
superticial pars reticularis. The hair follicles
were narrow and in most instances devoid of
shafts in this region. There was some telangiectaais of the capillaries and slight mononuclear cell infiltration. Some of the large elastic fibers in this region showed shiht swelling
meme a ee
Second series—7th and 8th weeks poat-ea-
for a few persistent areas of atrophy with nar-
rowing of the epidermis and finger-like down-
narrowing of the stratum granulosem. In such
areas the basal cells often showed increased pigment. There were many outward epidermal
egcrescences covered by thickened stratum cor-
neum, still loosely laminated ( Plate 25), which
probably accounted for the “orange-peel” sppearance of the akin noted grossly.
In almost
all instances the basal layer was intact with little or no disorganization. There were a few
scattered areas in which occasional epithelial
cella with pyknotic nuclei and perinuclear cytoplasmic halos occurred in the malpighian layers
(Plate 26). There were occasiona! arcades in
which the epidermis and particularily the
stratum granulosum appeared to be widened.
These occurred primarily in relation to contiguous sweat gland ducts where the latter penetrated the epidermis. .\ narrow zone of perakeratosis and amorphousdebris was st1!] present
bet ween the stratum granulosum and the loosely
laminated stratum corneum. The stratum
lucidum was not apparent.
Dermis.
The capillary loops in the dermal
papillae were not uniformly distinct.
Peri-
cytes remained in increased number but fewer
lymphocytes were present. Generally, there
was a slight telangiectasis of the capillaries in
the pars papillaris and the superficial pars reticularis (Plate 27).
There was some edema
of the pars papillaris (Plate 25).
Scattered
pigment-laden chromatophores were irregulariy
distributed in the papillary layer (Plate 26).
In some cases hair shafts in the superficial pars
reticularis were narrow or absent; in others the
hair shafts appeared normal.
Small hair fol-
licles (Plate 25) and sweat ducts in some cases
showed mild atrophy.
es