EFVECTS OF IONIZING RADIATION a4 2.9 Summary and Conclusions Tre Cuxn ar Fixptxes in a population accidentally irradiated by fallout material from nuclear device has been presented. The more seriously irradiated individuals had initial symptoms of anorexia, vomiting and diarrhea which subsided without treatment within 2 days. The same individuals slowly developed granulocytopenia and thrombocytopenia unas- sociated with secondary complications. The only other manifestations of radiation exposure obeerved were skin lesions and epilation, described in detail in Chapter III. The incid: nce of infectious and noninfectious disease in the more severely exposed groups was no greater than that in the least exposed group. If. after irradiation, the platelets and leukocytes fall in & manner and to a degree similar to that obyerved here, it can be predicted that no hemor- rhage or increased susceptibility to diseases similar to those observedin this study will occur and that no special prophylactric measures will be indicated. The use of prophylactic meas- ures, however. should be evaluated interms of existing conditions. With the degree of hemopoietic suppression observed there is a possibility of increased susceptibility to more virulent pathogens than were present in this incident. References . Danham. (') L, Croakite, aml Warren, § EB P.. LeRoy, G. V.. Atomic Bomb Injery, J. A. M. 4. fh?, MM, 1961. Cronkite, E. P. The Diagcnosia, Prognosia, and Treatment of Radiation Injury Produced by Atomic Bombs. Radiniogs 56, 681-080, 1961. . Bond, V. P.. Silverman, MW. 8., and Croakite, E. P. Pathageneais and Prthology of Post-Irradiation Infectious. Rad,, Reaverct |: 34R-~400, 1964. . Allen, J. G.. Moulder, P. 4... and Emerson, I), M., J. ALM. 4. 155, T04-711, 1961. . Coulter, MP. and Miller, RB. W. Treatment with SMacvessive Antiblotics on Dogs Exposed to Total Body X Irradiation. University of Rochester A. ELC. project report Cit-276, 1968, Cronkite, BE. P.. and Brecher, G. Protective Bifect of Giranulorytea in Radiation Injury. Aan. N.Y. Aced.af Nei. 58. 815—-4SR, 1065. . Barrow, J.. and Tullia, J. LL The seqoeare uf Cellular Responses to Injary in Mice Expused te Vip of Total Kody N-Hadlation. AMW4 Arch. Path. 3.47 08-47, 108. . Brecher, (2. and Crookite, E. P. Lesion uf Allmentary: Tract of Doss Exposed to 300-300r Whoie Kedy X-ray. 4mer. J. Path, 27, 6T6-@TT, 1951. . Cronkite, E. P.. and Brecher, G. Effects of Whole Body Radiation, ian. Rev, Med. 3, 188-214, 1062 10. Bond, V. L, Conard. K. A. Robertaon, J. 4. amd Weden, E. The Mix-Month Postexposure Survey on Marxhallese Exposed to Fallout Radiation. prean, it. Crookite, BK oP. Dunhaw, ¢. In L., Geiffa, David, McPherson, % D.. and Wootward, K. T. Tweive Menth Poatexrposure Surve; on Marshallese Expeaed to Fallout Radiation. Brookhaven National Laboratory report, to be published. 1965.

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