- 25 ¥ Others have observed carcinomas and sarcomas in rats and mice after intense exposure of the skin to ionizing radiation??743, Cancer induction is generally a frequent event tal in these experiments. Even at elevated doses, such as oer 12,000 rad of 1 MeV electrons, Boag and Glucksmann induced oo. “5 sarcomas/100 cm2 in rats>’. A few results for rabbits, obtained at Hanfora?®4?, sheep, Despite the and Swine were small number of animals * 37/ Withers, H.R., “The dose-survival relationship for .irradiation off epithelial cells of mouse skin," Brit. J. Radiol. 40, 1967, pp- 187-194. 38/ Hulse, E.V., “Tumours of the skin of mice and other Gelayed effects of external beta irradiation of mice using 90sr and 34P," Brit, J, Cancer 16, 1962, pp. 72-86. 39/ .-Boag, J.W. and A. Glucksmann, “Production of cancers in rats by the local application of Beta-rays and of chemical carcinog2ns," Procress in Radiobioloazyv, J.S. Mitchell, B.E. Holmes, and C.L. Smith, eds. Proceedings of the Fourth International Conference on Radiobiology held in Cambridge, 14-17 August 1955. Edinburgh, Oliver and Boyd, 1956, pp. 476-479. 40/ George, L.A. and L.K. Bustad, "Gross effects of beta rays on the skin," Hanford Atomic Products Operation, Bioloszy Research Annual Report for 1356, HW-47500, 1957, pp. 135-141. 41/ Georce, L.A. II, R.L. Pershing, §. Marks, and L.k. Bustad, "Cutaneous fihrosarcoma in a rabbit following beta: irradiation," Hanford Atomic Products Operation, Biology Research Annual Report for 1959, HW-65500, 1960, pp. 68-69. 42/ Ragan, H.A., W.J. Clarke and L.K. Bustac, “Late effects of skin irradiation," Battelle-Ncrthwest Laboratory Annual Report for 43/ 1965 in the Biological Sciences, BNWL-280, Karagianes, W.T., E.gp. Howard and J.l. F 1956,pp. a Northwest Lazcratory Annual Report for 1967 to the YENL of Biolosy and Medicine, - 1968, op. 1.10-1.11 Vol. I, Biclocitcit Sciences, E 12-1.