tacitly assumec,
eancec
inttiation should also ve
uracticg was adopted.
regarded as a “syst em”
serfous
encountered.
reason for
the acsucbec
toc whier a
to wnich an
conceptcal
‘natle a aumber of
ents communication,
the
“orp3n Gdose”
and
tollowin, which
iicsricultie
ve
detanied
luter
tnittal unjective ts stroly t
incicate
tne
this attempt to use
to
method
the evaluation of
of
application
followed by a more cetarled anu
ts
ves
the ois
for LLE tnet rejuires Hh
cisk from LLE, ana how
the evaluation of risx frou LLE,
the
ts
these problems will be
A neW approach
to
to
could te applfes.
otecatiocal
the ditficulties associated with
can be applied
cose
iutiaes nopulatioa conia
concepts and quantities appropriate for HLE,
conceots.
the celevant parameter fs
Avsutbed cule Alsu continue:
using “simple cell systems”
However,
that
the expression si u
Ce
tumor is observed in an organ or ofgzuas,
since
a
Le appacently was
we
discipline.
ts
tnen presented,
geserlbed.
Vuis
technical ceserigttion of
is
then
tne underlytis
concepts ang methodoloztes.
The Problem and tne hew sAsproach
A tact central
will ae
that
of
is,
tnis
tne nees for a res approacn to LLE rise evaluatiot
point sinp.l- be stated, arg then
the a0surSed cose .
that otgan
radiatlon
interest
curves
fa terms of
is
Shown
the
Fig.
1,
the cadiatisa suurce,
Thus,
in
the
the absorbed
typical
dose
surzan
Shown
on
population of
conceptually
to whic.
wished’ to Know
the dose
to
tu
of
50g14s2
the ceils.
tn
ise
popucetion
reszronse
adscissa
the exposure
shoul:
in
Thus the basic problem appears
that encountered by
wt
ce
tercs
the organ.
to “2
the early physicians whey
‘he raclobiologist concerned witn
tne study of single cell-initiated eftects must Se
of eneryy deposited
js:
r=
the cell population of an organ or other cell
interest {s exposed.
Identical
the
Taart
and ffele of
dose-celi
is
e|expessre
the physical quantity fluence.
regarded conceptually alsznough not numerically, as
particle fluence,
tne Guaitity
cell pepulation st an organ or cther cell
exposed.
in
Thir
the annder of pritary and secondary carticles
which is a parameter of
ta whicn
later deronstcrated.
ty ani orszan is comceptually
expressible
*t {s conceotually
unlt area,
of
to
interested tn
the cells--not truat whic tay Se
in
the occunt
tre environ e1f