The present system could
quality and LET;
in principle obviate
the
need t
ftfLeld quantities; a “Standard radiation”,
c2diatioa
linear “dose
effect” and “dose response” relationship; ciskx coefticients; 3254;
equivalent and cem.
accurately
Che
The problem of
cadfatiton tield
difficult, whether one uses
ovtataine meusurements that cepresenut
in tissues and cell populations
the current SE or
is
sf course
the proposed £5 approaches.
A rather far-reaching conclusion is nossidle with
the vroposed
Each relevant organ system in the body contains enormous auabers
of cell alements.
possible,
With
the proposed approach embracing
with any exposure,
individuals have approximately
in principle,
«>
we thea
for a given exposure, a population of individuals
these numbers can
transformea cells.
With a graded series of
then be correlated with cancer ftucidence,
which can be evaluated only long after the exposure,
beings.
e
Assuming all exposed noraal
the same number of relevant cells,
with known and equal numbers of
exposures,
-
to estisate the (fractional) nunber sof
transformed cells in the individual.
can have,
tne NSEr,
ye
approach.
dose
in aninals cr in heaan
The result would be a function for cancer risk as a function of
the number of
transformed cells inthe individual,to reolace the
currest
organ dose-cancer incidence function.
The significance of
system,
cancer
the above is perhaps
one can derive only a quite uncertain estimate
from a
physical
quantity,
and
equivalent in very large populations
individual.
individual,
obtained.
one must
use
the
to evaluate the
of
in the preseat
the risx of
collective
lose
risk of cancer in te
On the other hand, with the proposed system, one has a neasure
of actual effeccr,
vs.
substantial.
i.e.,
the fraction of quantally responains celis,
from which the cancer risk tailored to that individual can te
In other words,
the function for the probability of an eftect
the amount of exposure may in princisle be by-passed completely.
one has
in the
in principle removed
the evaluation of
Thus
risk from the realm of Ph in
which the focus is offictally Limited to the health of the populacion or
society,
health of
and placed it in the Md category,
the individual person.
buc in the medical,
social ana legal
With respect to the probab{liry of causation (
1?
SOG 14 bb
focus is oa the
This may have many iuaplications, not only
in radiation biology and protection,
spheres as vell.,
in which the
), it