Table 2

72-h culture:

Chromosome abnormalities in peripheral lymphocytes of the fishermen,
data from 1965 to 1967.

cases
examined

No. of

cells
analyzed

Aneuploid

Control

10

693

2. 88

Fishermen

13

881

2.05

Fishermen

15

1102

2. 90

Fishermen
1967

16

1248

2. 48

10

750

2. 27

12

950

2.00

No. of

Cases

1965

1966

48-h culture :‘

Fish
| 1965

Fishermen
1967

cells %

i
|

unstable

Stable

cells %
(i )*

0.14

onl

cells %
(/)*

i
i

0.14

\

(1/10)

(1/10)

(9/13)

(3/13)

(14/15)

(5/15)

first signs of regenerat
with following
;
posure,

So

0. 46

2. 23

3.45

2. 88
(15/16)

The hematologic

0. 45

1954 were reported *

0. 56
(6/16)

the
dose soon a ne

1. 20
(6/10)

0. 67
(4/10)

(9/12)

(6/12)

Generally speakii

sons. should
findings. From*bi1S }

to decide the theral

As to the Jap

0.74

2.11

abnc

and morphological a
tions of recovery were ‘

necessary to detect
mat«
observed in he

* Number of cases showing the abnormal cells per total number of cases examined.

so high (Table 2).
2. Unstable abnormalities such as dicentrics, etc. were observed (Table 2).
3.

The frequency of stable abnormalities was remarkably higher than

in controls (Table 2).

4. The detailed analysis of stable cells revealed that stable abnormalities
were divided following 3 types:
a. stable cells with balanced chromosome constitution... 67 per cent

b.
c.
5.

stable cells with deletion of a chromosome .:.29 per cent
stable cells with excessive chromosome material...4 per cent

In 3 cases small chromosomes which are similar to the Ph! chromo-

some were found.

.

.

.

.

6. The examined fishermen wereclassified in3 groups according to the
degree of the injuries indicated by the minimum values of neutrophils
shown shortly after the exposure. It was found that the mean valuesof stable
and of unstable cells were higher in proportion to the extent of the initial

damage.

Minimum values of neutrophils roughly corresponded to the estimat-

ed external radiation dose.

tem
=>
eee tte mn

-

Hematological

T. KUMATORI

70

4

Amano, 5. (1953) :

Gakujutsu 5

Anprews, G. A+

Diagnosis *
Organizatior

Cronkite, E.P-.
lonizing Re
Washingtol

Guskova, A.B.

Conferenct

New York.
Hasteruk, B.
Conferen¢
New York
HEMPELMAN, ~
Medicine

7. Chromosome abnormalities in bone marrow were observed in 5 cases.
All of these abnormalities were limited to stable abnormalities. While stable
cells in the peripheral lymphocytes showed various karyotypes of their own,
these in the bone marrow were limited to only a few karyotypes.

ISHIHARA, TIsnmmana, T
North H
i T-

SPERMATOGENESIS

Janmers

As a generative tissue, spermatogenesis has many similarities with hematopoiesis. Therefore, the changes of number of spermatozoa is described for

einitate
Kimura, K.

reference. The number of spermatozoa decreased, and minimum numbers were

obtained in 16 cases about 8 monthsafter the exposure.

Lowering of mobility

1, T-

Influer
the Fr

Select target paragraph3