Appendix V Findings of Epidemiological Studies of Cancer in Irradiated Populations (From J. Shapiro, Radiation Protection, pp. 260-4, Harvard U. Press, Cambridge, MA, 1972) No of cases Subject of study |. Hiroshima and Nagasaki A-bomb survivors (bomb exploded 1945). Brill et af., 196281) 2. Hiroshima and Nagasaki A-bomb survivors (women). Wanebo et al., 1968 (238) 3. Hiroshima and Nagasaki A-bomb survivors exposed prenatally. Follow-up time (yr) 5-13 13-21 10 Dose (R or rads) 0-20 21-80 &1-320 No. of persons® 85.070 13,184 8.695 Form of cancer Observed in expased group? Expected if nat —eexposed® 21 6 24 19.1 3.0 2.0 Leukemia Leukemia Leukemia 0-9 10-39 40-89 90-199 >200 Unknown 3,082 1,262 857 802 84) 840 Breast Breast Breast Breast Breast Breast cancer cancer cancer cancer cancer cancer 3 5 2 5 6 2 7.3 3 2 2 2.3 2.3 Unexposed 2,458 Breast cancer 2 6.1 control >64 500 person-rads4 1,292 All cancers 1 0.75 Jablon and Kato, 1970 (93) 4. Japanese A-bomb survivors exposed within 1400 m of detonation (died 1950-1962). Angevine and Jablon, 1964 (95) 5. Children exposed prenatally due to 17 1.215 All cancers, autopsies except leukemia 2-12 6] 56.8 10.5 39,166 Leukemia 9 77.000° All cancers 85 abdominal x-ray to mother (exposed 1945-1956 and died before end of 1958). Court Brown et al., 1960 ¢ 239) 6. Children exposed prenatally (born in 1947-1954 and died before end of 1960). MacMahon, 1962 (240) 4-13 1-2 7. Infants who received irradiation of chest before age 6 mo. in treatment for enlarged thymus (treated 1926-1957, follow-up in 1963). Hempelmann et al., 1967 (160) 13-38 61-600 60 Lower dose Thyroid group Thyroid (benign) 2,207 Leukemia (32,226 perSon yr at risk)! 4 6 3 0.07 80 a) Higher dose Thyroid group: Thyroid (benign) 498 Leukemia (11.485 person yr at 14 15 3 .06 .60 57 G 0 0.03 0.95 risk} 8. Infants irradiated routinely with X-rays to anterior mediastinum through small (4 X 4 cm) port, 7 10-20 75-450 mostly 150 1 40L, including 244 days after birth, as “apparently with en- harmtess and perhaps beneficial procedure” (x-ray 1938-46, fol- larged thymus Thyroid carcinoma Leukemia low-up 1956-58). Conti et al., 1960 (146) . 9. Children treated with x-rays to head, neck, or chest for various >I <50 (4%) (83%) 50-200 (36%) benign conditions, mainly ‘‘en- Upto 23 Not given x-rays for enlarged thymus, pertussis, and head and neck diseases; and died before age 23 (treated 1930-1956; fallow- up 1940-1956). Murray et al.. 1959 (241) cc vv oe uuu “a? Thyroid Thyroid (benign) 3,872 Leukemia Vt ? 0 0 200-600 (33%) larged"’ thymus and adenitis, treated before age 16 and followed till age 23. Saenger et al., 1960 (202) 10. Children treated before age 16 with 1,644 - 134 - ? 1.4