Table 21 Kinetic Analysis of ‘**I Studies Location and year Marshalls, March 1965 Subject No, Exposed* Unexposed* BNL, June 1965 0.81 Thyroid fraction® 0.67 Todide space, liters 0.40 (0.33-1.27) ——-(0.25-0.65) 0.79 0.52 (0.23-1.47) (0.26-0.77) 1.20 1.71 0.41 2.12 2.30 1.81 0.62 1.88 0.81 1.08 1.56 0.36 0.66 3 0.52 0.005 0.01 5 0.86 0.14 0.14 69 {partial thyroidectomy) 1.13 0.15 0.12 33.3 2 (partial thyroidectomy) 2 pre TSH post TSH post FSH 64 pre TSH post TSH BNL, June 1966 1.10 (0.34-2.57) Thyroid,” per day (0.17-1.99) ' 20 pre TSH Marshalls, March 1966 Urine,’ per day 0.80 1.40 1.19 0.60 0.49 1.53 0.92 0.37 20.0 61 (on thyroxine) 1.26 0.58 0.31 29.0 54 0.50 0.69 0.58 65 1.08 0.72 0.40 20.4 59 (on thyroxine) 1.65 010 0.06 «169 42 pre TSH post TSH 1.87 0.69 1.29 1.30 0.41 0.65 61 pre TSH | post TSH 0.50 0.13 0.48 0.78 33 pre TSH post TSH 0.20 0.45 0.97 1.57 0.82 0.78 65 pre TSH post TSH 1.83 2.35 0.82 1.14 0.31 0.33 59 pre TSH 3.53 post TSH 1.29 1.67 1.51 3.09 0.77 0.30 0.71 *Fraction of extrathyroidal iodide excreted in the urine per day (A,,). *Fraction of extrathyroidal iodide transferred to the thyroid per day (A.,). “Theoretical thyroid uptake, A.,/(A..+A.1)- ‘Mean andrangeof 12 subjects. *Meanandrangeof 9 subjects. signs of hypothyroidism: coarse facial features, dry skin, and Achilles’ reflexes with typical sluggish return. There was no palpable thyroid tissue. They did not show apparent mental retardation. TSH levels (Table 20) were markedly elevated in both boys, corroborating the presence of primary hypo- thyroidism. Figure 28 shows bone age retardation 5008321 EE ew me te etme in one of these boys. Typical bone dysgenesis associated with hypothyroidism** was noted in 1963 in these boys. Figure 29 shows such changesin the heads of the humeri in one case (No. 5). From Table 20 indications can be seen thatsev- eral other children with thyroid abnormalities (subject Nos. 2, 20, 33, and 65), some of whom