Table 21
Kinetic Analysis of ‘**I Studies
Location and year
Marshalls, March 1965
Subject No,
Exposed*
Unexposed*
BNL, June 1965
0.81
Thyroid
fraction®
0.67
Todide
space,
liters
0.40
(0.33-1.27)
——-(0.25-0.65)
0.79
0.52
(0.23-1.47)
(0.26-0.77)
1.20
1.71
0.41
2.12
2.30
1.81
0.62
1.88
0.81
1.08
1.56
0.36
0.66
3
0.52
0.005
0.01
5
0.86
0.14
0.14
69 {partial thyroidectomy)
1.13
0.15
0.12
33.3
2 (partial thyroidectomy)
2 pre TSH
post TSH
post FSH
64 pre TSH
post TSH
BNL, June 1966
1.10
(0.34-2.57)
Thyroid,”
per day
(0.17-1.99)
' 20 pre TSH
Marshalls, March 1966
Urine,’
per day
0.80
1.40
1.19
0.60
0.49
1.53
0.92
0.37
20.0
61 (on thyroxine)
1.26
0.58
0.31
29.0
54
0.50
0.69
0.58
65
1.08
0.72
0.40
20.4
59 (on thyroxine)
1.65
010
0.06
«169
42 pre TSH
post TSH
1.87
0.69
1.29
1.30
0.41
0.65
61 pre TSH
|
post TSH
0.50
0.13
0.48
0.78
33 pre TSH
post TSH
0.20
0.45
0.97
1.57
0.82
0.78
65 pre TSH
post TSH
1.83
2.35
0.82
1.14
0.31
0.33
59 pre TSH
3.53
post TSH
1.29
1.67
1.51
3.09
0.77
0.30
0.71
*Fraction of extrathyroidal iodide excreted in the urine per day (A,,).
*Fraction of extrathyroidal iodide transferred to the thyroid per day (A.,).
“Theoretical thyroid uptake, A.,/(A..+A.1)-
‘Mean andrangeof 12 subjects.
*Meanandrangeof 9 subjects.
signs of hypothyroidism: coarse facial features, dry
skin, and Achilles’ reflexes with typical sluggish
return. There was no palpable thyroid tissue. They
did not show apparent mental retardation. TSH
levels (Table 20) were markedly elevated in both
boys, corroborating the presence of primary hypo-
thyroidism. Figure 28 shows bone age retardation
5008321
EE ew me
te etme
in one of these boys. Typical bone dysgenesis associated with hypothyroidism** was noted in 1963
in these boys. Figure 29 shows such changesin the
heads of the humeri in one case (No. 5).
From Table 20 indications can be seen thatsev-
eral other children with thyroid abnormalities
(subject Nos. 2, 20, 33, and 65), some of whom