Range 1726-2001 87-101 3174-9078 160-458 From the above the minimum estimate of cancer risk would be given by a risk coefficient of 87/106 person rem and the maximum by 458/106 person rem. Thus, these two risk coefficients were used to define a range of estimated cancer deaths. 2. Genetic Effects (from Page 1 & 2 BEIR-1) a. Based on specific defects 5 rem/30 year reproductive generation would cause in the first generation 100-1800 cases of dominant diseases and defects per year (3.6 million births/year) or 5 times this amount at equilibrium. an increase of 0.05% incidence at equilibrium. The 1800 cases represent per year first generation and 0.25% In addition there would be a few chromosomal defects and recessive diseases and a few congenial defects due to a single gene defect and chromosome aberrations. The total incidence at equilibrium at equilibrium, is 1100 to 27,000/year. These the maximum would be 0.75% or 0.15% in the first generation. These are equivalent to 0.15% per rem at equilibrium and 0.03%/rem in the first generation. b. Based on overall ill health. of ill health is proportional Overall ill health: 5% - 50% to the mutation rate using 20% and doubling dose of 20 rem, 5 rem per generation would eventually lead to a 5% increase in ill health. Thus the rate of overall ill health is 1%/rem at equilibrium or O.Z%/rem in first generation. For estimating the potential genetic derived health defects in the Bikini population it was decided to use a risk coefficient per rem in the first generation recognizing very conservative. of 0.2% that it was probably