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coocevcsecebly the
whee
dey, however, the pereentage of nodal
Cells had returned to within normal linits,and reneined 0, for
the rest of tha period of observation,
Also the sésth day marked
a decline in the number of cells with structural abnormalitics,
Dut even on the last two days of observation these were present
dyiibic
in 9 to 10% of the cells.
In doth patients unusual numbers of polyploid eelis
were seen,
Perhaps the most striking inerecee wag that oecurring
twentyfour hours after the X-ray exposure of the seeond patient,
At thie time 11 polyploids were noted during the finding and
eounting of 100 eells with diploid or near-diploid nusbers,
Pindinge similar to those reported in this consunication
have also been noted by ue in cases ef chronie ayeloid leuksenia
following X-ray treatment,
These will be discussed in a separate
that X-rays readily produce chromosoze dasage which can be detected
in cultures of hasan bdloed cells.
Much gore work will be
necessary to achieve a fuller understanding of the pattern of the
ery Lye Ge
In conelusion, the data indicate, sa sicht be expeeted,
ron sy perele
comaunieation (Baikie et al, in preperation).
ehanges, partioularly,the effset of varying such physical peraseters
damage produced by a aingle doee of 250 rada, limited to the skin
ever the spinal colum, gives grounds for hoping that the relation-
Liebeak Meee ecat teER OY
ON rete tee
The extent of the
tee
of Goee ag the total dose and the dose-rete,
ship between radiation dose and the eztent of ehromesone damage in
man may be evaluated by direct observation ever a wide range of dose.
We are indedted to Professor %, Fo*hirter ent his staf?
for access to patients under their care, and to Kise NM. Braugten and
7
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Karin
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erro.Ty
lehbel ‘a. "fougs.
Puckton,.
¥.Be
ede
Baikis.
Tielle
Court-Brown,
bee.
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Glasg.
eRe ePeBe
uBR.
A,5o,.
at.
Ande
ation
Me. oC. Clinical *ffects of Radi
Research Unit,
we
etme mt
Western General Nospital,
gs
_RDINBUROA. 4.
DOE ARC BYES.