DOCUMENT
So,
Lawrence Be
rkel
Chives and Reey‘Labetory
cords one
;
airl
aeae
Ae,
=ee
perer
1?
cure about 30°Aof my animals,
‘They turned out sterile, and it
was a very careful dosage routine I had to follow.
SSH:
How were you determining the dosage?
KGS:
Well, I got a standard
from McMillan.
McMillan said, "This
standard emits 500 aiphe”particles /ory~see,—mst-haue
A
Seon—bets—partictes—though} per minute, and I built myself a
standard out of uranium oxide, which was a powder
}
wh ant it
to discharge the electroscope at the same Tatas)saad
Bet
See
cantanteent 500 erentoene
the niera,
curides
ig.
the
amount of any isotope,
dia@ategration rate of a certain
M1 of our radioactive phosphorous
was Based on that standard.
a
SSH:
How did you determine biological effectiveness?
KGS:
By blood counts, mostlyg GaPie they fell out of sight, why,
usually the animals would die.
Go¥ asa you| find that there was ee localization?
Well, tathe bone marrow.
GP ghose,
Sieys the very beginnings
of cadiokostaphyn there—daxe? (Breiner people in the Lab,
whose names I've been trying to remember, who were physicists,
a
(oPrhelpful to, bus
A
SSH:
A
I've read something stating that Hamilton was responsible for
developing the technique of radioautography.
KGS:
No,
Prieta
Neit af
‘We had a Dorothy Axelrod who made nany radioautographs,
a
Orn:
Voith abetly
plutoniung/because
it*s an alpha matteryA you get
en
’
beautiful pictures.
:
;
the Wd *
$38:
But that was later, wasn't it? That was thedzmore-
RCS:
Much, much later, yes.
SSH
De you know anything about whe was responsible for the initial
developuent of the technique?
dowe
Was that dew at Berkeley?