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Senator Ror'ia,

BEST COPY AVAILABLE

"(2) Premature aduinistration of antibiotics mirht have
obscured medical indications for treatment ..."

Most bacteria will ‘evelop resistance to antibiotics after
a peviod of time.
Thus iv one vives antibiotics prematurely and
there is an invasion of commensal or anisms takin. place and the

antibiotic would suppress the clinical siyns of infection and

at the same time, the bacteria mav be Jevelonpin:. resistance
antibiotic.
Thus, one would lose the capability of usin; a
able ascent if and when @ fran infection ceveloped.
In my
antibiotics ave seidom neeced prophylactically particularly

iucividcuals areunder continuous observation.

:

to the
valopinion,
when

Cerviainly in auimals, it has veer deconsirate. repeatedly
thet one can control the infections

thar se elop in the irradiatec

animal by acministerin; antibiotics wher the infection cevelops.
Question: What is the normal procecure when 2 phvsician
encounters a patient with a ,ranulocyte vount of 7%) 7?

The patients are observed carefully with white counts bein:
set

he inte: in, while

ot

:
'

ey

avd ceternliue its sensitivity to antibiotics.

L-

ore acministers a Lvoau
Ie

Waitin for the bacteriols, ical sta nesis,
spectrum antibiotic in hi. h uosa:e.

cst si 7. af infection,
qe
Lil, Ov, anigus
Oa

performec at re ular intervals anc ai the fbacterial cultures are vs c to isolate the of

ii “

BOX No.

1; Decembe:

BeoookAAVéW) WAT. £46

Cuestionu:
Uhat risk to the patient is tnvolvec in not
irmeJietali. adriiisteriaz
scopis lactic Lrestoeny fy Such & cage.
TFoo;¢

ospibudes thes@ is ne vit...

of conti sian

lhe Sideetlon until

Gee any. .es

the bone mar:o,

the peoiabiiits
recseuetee ain

produces ai: a equate number of cvanulocytes.
If antibiotics ave
piven prematurely, one runs the ris of several difzerent types of
bacteria becomins

resistant to this antibiotic thus Jepri¥ingsthe

patient of an actibiotic vhich wav be vreeda’ at a later time to

i

/?

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