AC] A REPOSITORY COLLECTION 482 Crow ki(TE : Tr EC oLaS Robert A. Eu. eve Nf A¢ ConAd, FOLDER {LES a2 pe 45: ae Conarc, eewticanamnnen Ry M. D. Ce ori ite, M. dD. neuer to questions . . Ero. fey. Auswers . Senator Ror'ia, BEST COPY AVAILABLE "(2) Premature aduinistration of antibiotics mirht have obscured medical indications for treatment ..." Most bacteria will ‘evelop resistance to antibiotics after a peviod of time. Thus iv one vives antibiotics prematurely and there is an invasion of commensal or anisms takin. place and the antibiotic would suppress the clinical siyns of infection and at the same time, the bacteria mav be Jevelonpin:. resistance antibiotic. Thus, one would lose the capability of usin; a able ascent if and when @ fran infection ceveloped. In my antibiotics ave seidom neeced prophylactically particularly iucividcuals areunder continuous observation. : to the valopinion, when Cerviainly in auimals, it has veer deconsirate. repeatedly thet one can control the infections thar se elop in the irradiatec animal by acministerin; antibiotics wher the infection cevelops. Question: What is the normal procecure when 2 phvsician encounters a patient with a ,ranulocyte vount of 7%) 7? The patients are observed carefully with white counts bein: set he inte: in, while ot : ' ey avd ceternliue its sensitivity to antibiotics. L- ore acministers a Lvoau Ie Waitin for the bacteriols, ical sta nesis, spectrum antibiotic in hi. h uosa:e. cst si 7. af infection, qe Lil, Ov, anigus Oa performec at re ular intervals anc ai the fbacterial cultures are vs c to isolate the of ii “ BOX No. 1; Decembe: BeoookAAVéW) WAT. £46 Cuestionu: Uhat risk to the patient is tnvolvec in not irmeJietali. adriiisteriaz scopis lactic Lrestoeny fy Such & cage. TFoo;¢ ospibudes thes@ is ne vit... of conti sian lhe Sideetlon until Gee any. .es the bone mar:o, the peoiabiiits recseuetee ain produces ai: a equate number of cvanulocytes. If antibiotics ave piven prematurely, one runs the ris of several difzerent types of bacteria becomins resistant to this antibiotic thus Jepri¥ingsthe patient of an actibiotic vhich wav be vreeda’ at a later time to i /?