of complicated te een boay ee commen each (lity wa ree i Tre therapy. or any effective Probable Etfects of Therapy On clinical grounds, antibiotics, has gata severe hematopoietic depression occurring at dose irfadiation have y (20) alc in ; ; their Perman et al. Soi 4 that the survival ; the cumbLinea use of transfusions when needeu, studies. Subsequent (29) have clearly shown rortality from a near 106% fatal aose ; / rate of transtusions to eht ene mi o t hi ; transfusion stuuies by Sorenson et al. (2l) and . that one can consistently reduce to about IL. mortality in dogs by the blood supplenentea by platelet-rich plasna when red cells ate tot needed. This enables one to shift the sigroidal acse murtality curve of . vos . uncomplicated whole body radiation injury tu a much steeper one shirting at “the LDgy from approximately 300 rad in The 5% mortality is the oog to a shifted from reughly ZUG rad in a nearly vertical sigmoid mortality curve. _ tad little “although “anticipate survival time is moderately that antibiotacs, bluco little cver 400 rac. te about Sul After doses benefit is observed and wits preater the Beye how Furth irradiated mice. combined use uf high dosage of successive antibietics ana whole w woula shown ty ‘Yailler et al. (27) obtained no marked benefit from antibiotic ang therapy and Tobertsea., BR think It has been clearl, iucrease that antibiotics et al. ano enetey of © : one would fresh whole blcod and platelet increase the survival rate, on therapeutic ane trauma, burns, the absence 360 rad midline in the vicinity of levels of about 200 rad. © opsmnen ir estimates » thermal can make a first ,uess estimate is bolstered by the fact that patients given therapeutic tetai ; the in that the Lue, for mantis an one Thus, 10% and SO% is approximately 36U rad. : rag in excess of doses nu aninals increasea, traustueiuns ang Thus, tesulting 50% survive, one can platelet transfusions . would benefit hunan beings. Se The relatiouship of mortality in do,s and wan §: at antibiotics. bere exposed Bae ae to further points In Figure 2 gumma up to uepression the is shown radiation from a inportant in the granulocyte count role of the grautlocyte nucleat bomb infection anc value : count and the in agogs thet correlation ¥ ith percent mottality. The granulucyte curve at the far left is it augs a “that were exposed to about 600 rad midline dose. Note that the blood unts ceclined ana all animals were ceacg by &utopsy ite Ive infection was clearly the mortality was also ‘ount along with a longer the seveuth day cof eapousure. the wajor cause of death. 100% witn a slower decline survival time. At autupsy the in the next in jgratulocyte wajer cause ct pFeas