of complicated
te een
boay
ee
commen
each
(lity
wa
ree
i
Tre
therapy.
or any effective
Probable Etfects of Therapy
On clinical grounds,
antibiotics,
has
gata
severe hematopoietic depression occurring at dose
irfadiation have
y
(20)
alc
in
;
;
their
Perman et al.
Soi 4
that
the
survival
;
the cumbLinea use of
transfusions when needeu,
studies.
Subsequent
(29) have clearly shown
rortality from a near
106% fatal aose
;
/
rate of
transtusions
to
eht
ene mi o
t
hi
;
transfusion
stuuies
by Sorenson et al. (2l) and
.
that one can consistently reduce
to about
IL. mortality
in dogs by
the
blood
supplenentea by platelet-rich plasna when red cells ate tot
needed.
This enables one to shift the sigroidal acse murtality curve of
.
vos
.
uncomplicated whole body radiation injury tu a much steeper one shirting
at
“the LDgy from approximately 300 rad in
The 5% mortality
is
the oog to a
shifted from reughly ZUG rad
in a nearly vertical sigmoid mortality curve.
_ tad little
“although
“anticipate
survival
time
is moderately
that antibiotacs, bluco
little cver 400 rac.
te about Sul
After doses
benefit is observed and wits preater
the
Beye
how
Furth
irradiated mice.
combined use uf high dosage of successive antibietics ana whole
w
woula
shown ty ‘Yailler et al.
(27) obtained no marked benefit from antibiotic ang
therapy
and Tobertsea., BR
think
It has been clearl,
iucrease
that antibiotics
et al.
ano enetey of ©
:
one would
fresh whole blcod and platelet
increase the survival rate,
on
therapeutic
ane
trauma,
burns,
the absence
360 rad midline in
the vicinity of
levels of about 200 rad.
©
opsmnen
ir estimates
»
thermal
can make a first ,uess
estimate is bolstered by the fact that patients given therapeutic tetai
;
the
in
that the Lue, for mantis
an
one
Thus,
10% and SO% is approximately 36U rad.
:
rag
in excess of
doses nu aninals
increasea,
traustueiuns ang
Thus,
tesulting
50%
survive,
one can
platelet
transfusions
.
would benefit hunan beings.
Se
The
relatiouship of mortality
in do,s and wan
§:
at antibiotics.
bere exposed
Bae
ae
to
further points
In Figure 2
gumma
up
to uepression
the
is shown
radiation
from a
inportant
in the granulocyte count
role of
the grautlocyte
nucleat
bomb
infection anc value
:
count
and
the
in agogs
thet
correlation
¥
ith
percent mottality. The granulucyte curve at the far left is it augs
a
“that were exposed to about 600 rad midline dose. Note that the blood
unts ceclined ana all animals were ceacg by
&utopsy
ite
Ive
infection was clearly
the mortality was also
‘ount along
with a
longer
the seveuth day cof eapousure.
the wajor cause of
death.
100% witn a slower decline
survival
time.
At
autupsy
the
in
the next
in jgratulocyte
wajer
cause
ct
pFeas