ce, eeetT mabe pectsaPihaeean2 SORE wahhy aly PtBee 2a Gn we INTRODUCTION From perusal of the older literature and review of the Japanese experience at Hiroshima and Nagasaki (1), it appeated necessary to consider some broader aspects of radiation injury in general, produced by radiation injury, such as the syndromes the influence of depth dose of radiation, unresolved question of lethality of radiation in man, rate, and repair of injury during chronic exposure fallout fields decaying with the -1.2 law. the the role of dose to radiation as in Studies on pure radiation injury generally involve a single dose of x-ray or gamma rays at different dose rates, and it is rare to find sufficient data to evaluate the influence of depth dose patterns within the experimental subject. considers the numbers of animals used, the steepness of radiation lethality curve between 10% and 90% mortality, studying animals exposed to single dose of radiation, When one the sigmoidal the practice of one must consider the possibility that lethality differences observed may represent chance variation, not related to any therapy used. evaluation, In a retrospective literature these are questions that cannot be evaluated definitively. In Whole-Body Irradietion: ite se : os AE Fh atterns which will be considered later. Three, somewhat arbitrary ana The Central Nervous System Syndrome After large deses of several NS) syndrome is produced. thousand rad, ra MES ee ee shes : ed wea Tet The radiation syndromes produced by exposure to fonizing radiation are Pa tihpe 3% SERED 58h et Kkadiation Lethality - The Classical Syndromes Produced by Uniform ; atts ~ LTA to the antibilotics available, 1 a ‘tesistance ick Aap Ae5 nil t * _fegenerate before the commensal or invading pathogenic bacteria develop ee the bone marrow will the Central Nervous Systen: Death may occur during exposure in some -93- + : 3 3 os? of A crucial problem in radiation injury is whether ei ton trauma and individuals with tenporary marrow hypoplasia. ~ ok extensive burns, eee e nepe on * stated that antibiotics increase the survival rate of patients with ee emf aplasia produced by agents other than radiation, it can be categorically 2 pons ee aa eT ate Be tee trauma and thermal burns in nan aud formanagement of marrow —— Pearse sree fT, sclare : ee et management of CR ongapelEietiten food sehttorenitarareneciel x pe respect to therapy, vast human clinical experience on use of antibiotics in p wag erates RPrty TE ey war Fear erere