‘en; . : . Cyt tate 2 Toe TF et eh oe an,en ie a Loa ee Hematopoietic Molecular Regulators in the hanagement ot the Lone Marrow hypoplasia In the last ten years several molecular regulators of hematopoiesis have been identified, purified, sequenced, and by recombinant DNA techniques are” being produced in large amounts, These are interleukin-1 and 3, granulocyte- macrophage colony-stimulating factor, macrophage colony-stimulating factor, granulocyte colony-stimulating factor, endothelial celis, and fibroblasts produce granulocyte-macrophage colony- stimulating factor. accelerates to The latter the production of granulocytes and macrophayes izole upon in vivo administration produces a granulocytosis with accelerated setrum ~ production of granulocytes. funcetiunal granulocytes colony~stimulating factor accelerates in vitro the procuction of granulocytes in colonies and in vivo accelerates granulocytes and improves (50-55). mouse 4-5 times ry ae ap Ee aaNet ee rid has ‘it heh OLere Vs to near 48 hours before, administered " ae ay “rT trradiation, 100% IL~] survival. When the normal to primates aud mice four GN-CSF and G-CSF to produce a level as long as by radiation or chemicals and 100% lethal gose of radiation administered it is ineffective (50). to primates and shown been given (51-54). turns a near hours before have been sustainea granulocytosis the materials are administered. in which or the marrow has the granulocyte counts are of It been suppressed increased Erythropoietin has been shown to be of sajor benefit in Stimulating the production of red cells as a result of renal failure (55). combinations will in individuals with severe anemia It its assumed that these avents or be of potential benetit in tne with bone marrow Suppression as a result of whole other hand, it is conceivable that forcing cells body trradfation. into mitosis On the before DNA is repaired may fix genetic failure of the mitotic capacity of pluripotent stem cells or an earlier and incidence of leukemia. result individuals adequately increased injury and treatment of in either an early These are possibilities that need to be _ &xplored experimentally. a, | to hen administered 20 a in an 2 the bacterial-killing capacities IL-l has been used as a radloprotector. hours prior in the phagocytic and the production of -109- sor at ee “0 keep | Granulocyte ek y ec the effectiveness of the in phagocytosis and bacterial killing. 1 es ADS. It also increases ae in vitro and ee, See ie Lerman es stimulates T-cells, we . eoTe,whan v4. Whale . . i,oer eteoe Mie ma de ee eo macrophages, =. a3 with Interleukin-1], a product primarily of activated monocyte or PE aE cos ta atelePale aha ry rt erythropoilein. and BAGeSeeeas xe tion a * ye ro a” _ _7 Per 2 a nat . Cea : eM tt em ete soe