ee EY aeB cee ale sie eaSE 7. Granulocyte transfusions would be desiratle to prevent intection in patients with a sranulocyte count falling below 2OU/ul. these are not practical on any 5. large infection in dBacterial or fever flora, Since therapy even 4 In> is an arr a ne og - than 24 hours \ — .4 The onset ot have b ane techni ‘ ORR sensitivities and 3 : » wee therapy should obtained. If cultures are negative or fever ery thropote Macrophages produce eee e persists, = antibiotic therapy, Pon upon After initiation of broad-“spectrum? it should be continued until washed packed red blood cells should be given as indicated functional é colony-stimy to kee. &fanuloc the hemoglobin above 3.5 g. 10. All bleod products infusion into the patient in order proliferate and \1, should be linpair the possibility be within of a bone marrow uncertainty about inhomogeneity of the limits of Suppressed ana therapy. the dose, rescue of approximately 3800-2000 rad. bone below 800 rad transplants are rejected. From the and twin transfusion of abuve as an from . transplant. is bone marrow tror his indication for the earlier discussion experimental the ot conditions where uniform wnele “ody distribution of icentified. Although radiation dose oe oe.by radtatio n , a0 ne (51-54), transplantation, the was the depth-dose curves sea Jjuses used above were delivered ie in a absorpec enerpy. Aare power, wees Wout a pee Segate -108- IG | ay ™ Me OBETARTareaoe BE ALSSOLE eeBay befo ene ae has been sive ! et A genectthe al twin. radiation mouse -5 Above roughly 2000 rad theseas irradiation casualty exPoy certainty anc the hours immunity 15 not sufticient that doses anc yy. requirement that In ome bone marrow 7es ytes hours prior ; in the lymphocy tes collectea promptly, ‘the casualty w. the ideal donor. snown with any degree the magnitude of (50-55). 48 marrow transplantation, have beef HLA-typed and donors will have been identical that might ag tadilation dose, no lymphocytes bone marrow transplantation will ouly rarely be indicated irradiation casualty because dose &Tanuloc irradiated with 2U0U rad before to kill ji vive Production ¢ the granulocyte count rises above 500/Ll, fever subsides, and eviagence of infection disappears,ag . G9, gta accelerates Ss or with amphotericin may be considered. £ra colony-set, the most likely agent is an organtsm trom nornal bowel that are een niques indicattoq ~229 tnough cultures are ema ad include aminoglycoside and carbenicillin with <te:: oS additional antibiotics being adued as indicated by bacterial culture m Pj initial ' Fever with clinical signs of sustained more initiating systemic antibacterial negative. Aamittedly, than 38°C should aruuSe strong suspiciun of the aranulopenic patient. infection, a scale, Infection is the zreatest threut to life. signiticant fever greater for ere =o an