38 The bone tumors that were produced were single and multiple, and, particularly in rats and rabbits, there were many instances of metastases. Doses ranging fran 0.05 pCi/gm to 5.0 pCi/om resulted in "considerable mumbers" of tumors. Most of them (61%) appeared in long bones (Lisco et al., 197). Other work done at this time centered on the effects of 8%Sr on pregnancy and the transfer of the radfonucl ide fran mother to young via the ‘placenta and mammary gland (Finke), 1947). Animals exposed to 89Sr in utero © or prior to weaning showed retarded growth, malformed Jong bones, anemia and bone cancers. In a symposium on radiostrontium (Goldman and Bustad, 1972) effects of injected, ingested, or inhaled 90Sr in beaglesdogs were reported. Studies on 90Sr-treated beagles began in 1947 at Argonne National Laboratory, and were subsequently expanded tnto several large programs at the the Univers ity of Utah, at the University of California at Davis, and at the Lovelace Foundation in Albuquerque. In these programs, the beagle dog remained the experimental subject of choice (Book, 1980). The most significant effects in animals given adequate exposures to 905r have been tumors o osteosarcoma, and myeloproliferative disorders, which includes both neoplastic hematopoietic disease and preleukemic conditions. All spectes that have received sufficient 905r have developed osteoSarcomas, including dogs (Poo] et al., 1972, Dougherty et al., 1972; Finkel et a}.,. 1972), monkeys (Casarett et al., 1962), pigs (Clarke et al., 1972), rabbtts (Vaughan and Williamson, 1969), mice (Nilsson, 1972), and rats (Moskalevy et al., 1969). Myeloproliferative disorders have been noted in dogs (Dungworth et al., 1970), pigs (Clarke et al., 1972), and rats (Moskalev et al., 1969), Mice developed lymphatic Teukemia but not granulocytic Teukemta (Nilsson, 1972), °