44 During the March 1966 survey, ''*I studies were donein 8 subjects with thyroid abnormalities. In addition to urine and neck radioactivity measurements, as described above from the 1965 survey, 6 subjects were given 500 mg KCIO, by mouth =4 hr after the ''“I dose. Neck measurements were continued for 45 min longer. The neck uptake curves in these subjects are shown in Figure 30. In 3 subjects (Nos. 3 and 5, who had severe growth retardation, and No. 69, who had a subtotal thy- roidectomyin 1964) the neck uptake was almost enurely due to iodide circulating in the blood, no correction having been made for this factor. In 3 other patients (Nos. 2, 54, and 65) there was a brisk uptake to about 18% of the dose. Following KCIQO,. there was no loss of iodine from the neck If the thyroid gland had contained iodine which had been trapped as iodide but not organified, this should have been discharged by the KCIO, ‘\ phenomenon ofthis kind has been seen in radiauon-damaged thyroid glands after treatment of hyperthyroidism with radioiodine"! '- but was not observed in the Marshallese subjects. Computer analysis of the ''‘I data obtained from all the patients so studied is presented in Table 2!. This includes data obtained in the Marshall Islands in March 1966 and preoperativelyat BNL in June 1965 and June 1966..Computer analysisof the data obtained at.BNLin June 1966. was evaluated in several ways: with er without the corrected neck counts using a lead shield,with or without inclusion of urine data, None of these made an important difference in the value for thyroid accumulation rate, but théuncorrected data gave somewhat greater reliability. The very low urine excretionrates in some cases are probably due to incomplete urine collection, and result in comparable errors, in the opposite sense, in the computed thyroid fraction. In Table 21, uncorrected neck counts are uséd excéptfor the data al BNL, June 1965. In. the. -Marshail Islands in~ March 1966, blood ' "J was “measured.etcgand 4 hr in order to calculate theiodide space.“The data’ obtained in March 1965 on Marshallese-Without thyroid abnormality are included for comparison. The two cases with severe growth retardation (Nos. 3 and 5) had markedly diminished thyroid accumulation of ''-I as did one subjeet (No. 39). who was on thyroxine therapy and:one (No 69) after partial thyroidectomy. Fwo subjectsdNos. 2 cata figure 29) Bone dysgenesis of heads of humeri in subject No. 5, typical of hypothyroid disease.