Table 20 Growth and Thyroid Studies in Subjects With Thyroid Abnormalities Neck '*7] at 4 hr," % of dose Growth Subject 4 La No. and sex Year Thyroid abnormality — tested 3. M_ Atrophy 3 M_ Atrophy Chrono- logical . age, yr Skeletal ranking, yr Statural ranking,” percentile 1965 13 3 <10 1965 1966 13 5H2 <10 1966 Pre TSH Post TSH Serum iodine, pe% PBI 0.8 > 120 1.9 3.1 0.8 1.8 119 248 <0.5 372 <0.5 440 5.7 1.7 125 17 F Nodular goiter 1965 1966° {5 13%2 90 6.8(’64) 1.8 21 F Nodular 1965 15 15 10-25 8.1(64) 69 F Nodular 19654 16 16 2 M_ Nodular 1965 13 112 25-50 20 M Nodular 1965 19 Adult 25-50 72 *F Nodular 1965 18 17%2 >90 42 F Nodular 1965 15 13%2 10 61 F Nodular 1965 20 Adult 50-75 54 M_ Nodular goiter 1965 1966 13 13 90 19 M Nodular 1965 17 152 10 36 M_ Nodular 1965 19 18 75 33. =F Nodular 1965 13 13%2 >90 65 F Nodular goiter 1965 — 1966 13 10%2 <10 59 F Solitary 1965 35 64 F Carcinoma 1965 19664 31 40 M__ Solitary nodule 1965 40 goiter goiter goiter goiter goiter goiter goiter goiter goiter goiter nodule 1966° 1966° 1966¢ 1966 1966 1966° 1966 1966 1966 >90 1.3 7.1 6.5 18 TSH, ng/ml 1.4 3.2 8 T,I Serum 1.0 (29) (23) 7.9 4.2 (31) (31) 6.5 4.2 5.2 2.6 159 9.6 26.6 5.3 (15) (24) 57 46 12°(10) (24) 7.9 49 8.3 5.0 4.3 <3 <17 3.9 3.3 <17 4.3 <17 197 19 4.1 4.2 7.0 (16) (24) 59 3.8 (9) (14) 4.9 3. 2.1 1.9 7*(20) (38) 8.2 5.3 (19) (28) 86 4.9 3.4 2.0 17 86 <17 7.3 6.6 23.5 4.8 10.3 “Values in parentheses obtained at BNL. >Relative statural growth expressed as percentile ranking compared with growth curves of unexposed Marshallese children. ‘Assays in 1965 could not detect levels below 3 nanograms/m]. Seven unexposed children in the same age group had <3 ng/ml. Assays in 1966 could not detect levels below [7 ng/ml. Three exposed children without thyroid disease (Nos. 6, 8, and 32) had <17 ng/ml. Two children exposed tn utero (Nos! 84 and 86) and two unexposed children had <17 ng/ml. The 1966 levels were obtained about 3 weeks after cessation of thyroxine therapy, the 1965 levels, before therapywasinstituted. We are grateful to Dr. William Odell at the National Institutes of Health for carrying out these assays. , 4Post partial thyroidectomy. ‘While taking thyroxine.