33 cates some of the changes characteristic of these benign nodules. In one case (No. 33), in addition to adenomatoid nodules there also was present a Hurthle’s cell adenoma.In anothercase (No.61), one pathologist remarked that “some observers might regard the large nodule as a follicular adenoma.” In subject No. 59, a 46-year-old woman whohad receivedless than half the radiation dose of the other cases with nodules, there was a solitary adenomatous nodule, well circumscribed, and the surrounding thyroid tissue was normal in appearance. This was in contrast to the other cases in whom the glands were almost entirely abnormal in-appearance. A 41-year-old woman (No. 64) had a mixed papillary and follicular carcinomaof the thyroid with localized metastasis to a blood vessel and lymph node (Figure 26). Following complete thyroidectomy by surgery and therapeutic ‘*'] no recurrence or further metastasis has been noted. In September 1966, at Tripler Genera! Hospital, Hawaii, thyroid uptake studies following TSH stimulation (10 units daily for 2 days), thyroid scans, andskeletal surveys for metastasis showed absence of the thyroid and no detectable metastasis.* Thyroid Function Tests Related to Thyroid Abnormalities and Growth Retardation In Table 20 the cases with thyroid abnormalities are listed along with the growth status of children andresults of thyroid function tests. The re- sults of kinetic analysis of '**I tests are given in Table 21. Two 12-year-old boys (No. 5 and No. 3) Figure 24. Benign thyroid nodules at surgery. Top: ex- posed thyroid with arrows pointing to nodules. Bottom: sectioned gland from another case. Note multinodular, cystic, and hemorrhagic natureof gland. Microscopic Appearance. The microscopic ap- pearanceof all the benign nodular glands in the children was characteristic of adenomatousgoiter and varied mainly in the degree of change. The architecture of the gland was disrupted by the nodules of widely varying sizes. Some of the nodules contained microfollicular elements with and without colloid, others were atrophic, some contained large cysts with colloid, some with hemorrhage, andstill others showed extensive proliferation of the epithelial layers with marked infolding, giving an “arboreal” appearance. Figure 25 indi- who had been exposed at 15 and 18 monthsof age respectively have hadthe greatest retardation of growth and development. Subject No. 3 had shown no changein bone maturationsince 1961 and until recently had the bone ageof a 3-year old child. The bone age of No. 5 has shown continuing slow growth and in 1965 was 5%years. Both these boys in 1965 had the height of normal 7-year old Marshallese boys. Their dwarfism was particularly evident in comparison with younger siblings who weretaller than they. In 1965 it was found that in both cases the levels of proteinboundiodine had dropped below 2 ug%. Before that time, they had levels considered to be in the normal range, and there was no reasonto relate their dwarfism to hypothyroidism. With the development of the low PBIs they showed definite “Weare grateful to Major Ronald Moore, MC, USA, for car- rying out these examinations.