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of deposited rad) ymuchies is the induction of neopla
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heavy nucler, cle. ceices has beea demoustrated to occur either in increased
incidence or by temporal advancement of normal incidence with moderate to
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to much controverss see Dose-Response section).
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variety of olier agents. and there is growing interest in the role of promotiona:
agenis, i.¢.. co-carcinogens such as viral agents (33), and chemical agents (}. 341
Calvin (3*) speculates that the three most studied modes of carcinogenest-—-viral, chemical, and radiation—mas have a molecular process in common, although %r2t sreof of this has not vet appeared,
That these processes may involve somatic mutations has been believed possible
for at lee.t twdecades, Recent reconsideration af the pheromend of patoduc
and radein) toaicolvey on the theors of steady-state mutauon rates (76) reaso7s
the rl.
wtarcugh cna gener. basis using 2bsolute rate thee ry --a Oreekthroug: trom au: all-too-common dependence on stricily Gbserationa:
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