Nuclear Medicine Technology and Other Health Applications Extension and Improvement of Radiographic and Isotopic Project Title: 17. Diagnostic Techniques Expected Resules in FY 1974: RX-01-03-(c) (Cont'd,) In addition to work under the NIH contract investigating techniques for mammography, spectral measurements of radiographic tubes will be performed and the use of critical absorption filters for mammography and iodinated contrast agents will be studied in order to evaluate possible reduction in dose and increase in contrast, Studies in collaboration with the Chemistry Department will include iodine 123, carbon 11 and F-18 fluorinated amino acids, Thyroid imaging with orally administer [-123 will be evaluated using a smaller intravenously administered dose with dynamic studies of rate of immediate uptake of iodine utilizing a computer system, The ocular study with labeled 4-[3-dimethylaminopropylamino !-7-iodoquinoline(DMQ) will be continued in collaboration with Dr. Samuel Packer and extended to human patiencs., Comparativyé studies using ultrasound and P-32 should be carried out, Other iodinated agents should be evaluated, chiefly I-123 hippuran for renography, utilizing the MED II computer for analysis. Rose Bengal should also be useful for biliary problems, Dopamine, labeled with C-1l, has been produced in carrier free form, The degree to which it localizes in the adrenals is highly dependent on the specific activity and chat of the carrier free material is from five to seven Following : times better than our previous best material (40-50 mCi/mg). further quantitation in dogs, attempts will be made to visualize the human adrenals. indicated, If successful, an evaluation of hypertensive patients would be There are also possibilities of C-11 dopamine localizing in specific areas of the brain, particularly in combination with the admini- stration of monoamine oxidase inhibitors, Studies are to be performed first on mice, then on dogs, with the aim of eventual studies of parients with parkinsonism, Other biogenic amines including norepinephrine and epinephrine will be studied. An eventual goal is the labeling of L-dopa with C-1l1l and obtaining information concerning its disposition and metabolism in Parkinson's disease patients, F-18 labeled fluorotryptophan has been evaluated in animals and appears to hold promise for imaging of the pancreas, As soon as methods for assuring sterile and pyrogen free materials have been developed, application to human disease is envisaged. J collaboration with the Instrumentation Division work will continue mamission scanning apparatus, the positron camera, and semiconductors, An alfgption edge transmission scanning apparatus, developed and tested using phantoms and animals, appears to be useful for plotting and quantifying distribution of iodine in vivo in the thyroid or in other areas such as the biliary or urinary tracts after injection of iodinated contrasc agents. Application to patients will be started, All patients referred for thyroid work-up will have transmission scans, studied with injection of todipamide. Problems of (See Continuation Sheet) 1479221 the biliary tract will be Further instrumentation development RX-63