Nuclear Medicine Technology and Other Health Applications Extension and Improvement of Radiographic and Project Title: Diadznostic Techniques l6, Technical Progress in FY 1973: (Cont'd,) Isotopic RX-O1-03-(c? be completed in 1973 with travel and laboratory expenses paid by SAAEB, In addition, patients with primary hepatoma will also be studied, This hepatoma is nutritionally based, causes death within three months, and has a mortality rate of more than 150 per hundred thousand per year among the Bantu, A BNL research collaborator, Dr, Ludwig Feinendegen, Director of The Inscitute for Medicine, KFA, Julich, Germany, has requested a week's visit by the Principal Investigator to set up a collaborative study at Julich utilizing double labeled tryptophan, (Hankes ) 17. Expected Results in FY 1974: + “N Collaborative studies with the Department of Applied Science will continue on technetium labeled compounds, pulmonary function, indium L1l, myocardial agents and radiography. Erythrocytes labeled with Tc-99m have been used for vascular and splenic imaging. One detraction from widespread clinical use is the 60-70% efficiency of labeling which requires two cell washes. However, there are indications that labeling efficiency can be increased to over 90%. will greatly simplify the procedure and make it more practical, This : The helium leak detector test. determining time of airway closure in ‘ health and disease will be extended to a larger population group to determine normal parameters. It is planned :o follow up employees act yearly intervals. as a longitudinal study and to compare smokers, non-smokers, and former smokers, When abnormalities are detected, regional ventilation will be studied with radioactive gases. Xenon 133 can be used, but when Xenon 127 is available, this will be evaluated. The parameters of in vitro labeling of transferrin with indium lll will be studied and distribution quantified in animals, Plasma clearance, excretion, and distribution in human beings will be studied and compared to technetium-sulfur colloid, When iron 52 is available, similar comparative studies will be carried out, Thallium 201 will be evaluated further as a myocardial scanning agent. Studies will be continued in goats to determine degree of myocardial localization as well as patterns of distribution in ot loc rat ssues, Data will be used for dosimetry purposes, Thallium 201 also es in kidneys and the concentration, time of peak localization,and Y disappearance will be determined in animals and patients. There is evidence to suggest chat thallium may be useful as a tumor localizing agent, particularly in melanomas. system, This will be tested in a hamster melanoma (See Continuation Sheet) 1419220 RX-62