Biological Studies of Materials Arising from Energy Qperations Project Title: Interaction of Chemicals with Nucleic Acids RX-0 3-06-(b) 18, Expected Results in FY 1975: (Cont'd,) is expected that the survey of classes of compounds directly interacting with DNA and other nucleic acids and their availability as pure compounds will be completed in the first year. In addition, a number of these interactions will have been studied in vitro by various physico-chemical techniques, The determination of the molecular interaction by x-ray diffraction and model-building is a more time consuming process, and at most, 19. several complexes may be determined in a year, Description and Explanation of Major Materials, Equipment, and Subcontract Items: None 20.° N Proposed Obligations for Related Construction Projects: le oe ty: my: None RX-388 11719331