Effects of Radiation on Living Organisms
Radiosensitivity of Immune Responses and Mechanisms of
Project Title:
Immune Reactions
RX-03-O1-(b)
13,
Publicacions:
Terres, G., Morrison, S. L., Habicht, G, S., and Stoner, R. D.
Appearance
of an early "primed state" in mice following the concomitant injections of
antigen and specific antiserum.
J. Immunol. 108, No. 6, 473-81 (1972) 77 Fy/
Hess, M. W., Cottier,
The
intestinal
H.,
Sordat,
barrier to bacterial
B., Joel,
invasion.
D.
D., and Chanana, A.
Presented at
D.
the Conference
on ''A Re-Examination of "Non-Specific'' Factors Influencing Host Resistance",
Bern-Gurten, June, 1972,
14,
7
/ 7604
.
Scope:
A) 200 Word Summary:
A goal of this research is to determine the origin,
of lymphoid cellular elements in immune responses.
“N
function'and
fate
Of primary interest are
the highly immunogenic properties of complexes of antigen-antibody as compared
with the same antigen administered alone.
Five inter-dependent objectives are explored:
(1) radiosensitivity
of antibody responses, (2) comparative antigenic properties of complexed
antigen and antibody (specific immunoglobulins)
in their capacity to-elicit
early and enhanced primary antibody responses, (3) cellular proliferation
in germinal centers of lymphoid tissues during antibody responses, (4) rad-
.
~*
iation-induced susceptibility to anaphylactic shock, and (5) the genetic
control of antibody responses,
.
Another goal is to determine whether or not tumor virus infections and
‘
~
tumorigenesis are affected by exposure to radiation, and to compare the effects
of radiation on in vitro and in vivo virus replication.
determine if exposure to radiation will:
It
is proposed to
(1) enhance or depress both in vitro
and in vivo infection of cells with DNA and RNA tumor viruses, (2) influence
oncogenesis in genetically susceptible and resistant infected chickens,
(3) initiate tumors in non-infected chickens, and (4) influence the immune
response in genetically susceptible and resistant chickens infected with
DNA and RNA tumor viruses,
B)
with
glob
body
Supplement to 200 Word Summary:
protection normally conferred to individuals by active immunization
igens and vaccines and/or passive immunization with specific immuno-
rs
in the control of infectious diseases may be abolished after whole-
Sure to sub-lethal doses of ionizing radiation.
Exposure of animals
to ionizing radiation at various times before, during, and after immunization
affords a unique opportunity to study cellular and humoral immune mechanisms
as well as the repressive effects of radiation on normal immune responses.
Emphasis is directed in these studies to the highly immunogenic properties of
complexes of antigen and antibody in eliciting earlier and enhanced antibody
(See Continuation Sheet)
[119268
RX-175