Numbers fn Groups Adequacy of Controls . eo CHARACTERISTIC SOF AVAILABLE DATA ON THE HEMATOLOGICAL EFFECTS OF PENETRATING RADIATION Source of data Characteristics ee see een Bombings 48 47 Clinical Laboratory Radiotherapy® Accident x Large Small Poor Small Poor Japanese Fair Large Sanall Small Yes Yes Yos None None Minimal None Yes No Yes Yes No No No No No Yes Gamma, Hard x rays, gamma Gamma, neutrons, Gamma, beta Hard x rays, Yes Good Techniques? Chance of bias duc to Large Large sampling techniques “Normal’’ Yes individuals Internal None contamination Additional trauma necessary some ncutrons Poor Single exposure Dose r«te Yes Instantaneous ~Sr/min Body region Total body Usually partial body Geometry Depth dose curve Sublethal & lethal Narrow beam Moderate fal! Sublcthal Narrow beam Variable gamma to skin x rays, betas Good Usually no Dosage estimation Dosage Range 3 ' (burns etc.) Type of radiation Large Very good Good | Yer You Good Fair Species extrapolation Large Larie Animals** Good No Fair Yeu Counting Serial Counts Exposed Marshallese Poor Fair Goud Yes Yes Yes Instantaneous Varying, ~10r/min Sublethal Sublethal & lethal Narrow bean ~5r/hr Total body; Total body beta to skin Total and partial body Subicthal & lethal Narrow beam __ 360° field Rapid fall off Essentially off Vartable ‘rapid flat fall off to flat *Same technicians for all counts; rigidly standardized techniques throughout etc. Table 4.11 MEAN PERIPHERAL BLOOD COUNT VALUES FOR SEVERAL CONTROL POPULATIONS (x 10% 8 ‘ dati ource of data upanese Japanese Kure, 1947-1948 Total White Count 9.9 9.6 7.4 7.0 7.8 9.7 Neutrophiles 5.5 5.0 4.4 4.3 4.1 4.8 Lymphocytes 2.9 0.6 0.6 2.8 2.5 0.3 0.4 2.1 3.1 4.1 Eosinophiles 0.9 1.0 0.2 0.2 0.3 0.5 Q.1 0.0 0.0 250f 0.0 238 0.1 308 Basophiles Americans**? Platelets Americans® Controls Majuro Determination Monocytes 1948-19498 KwajAmerican 0.3 Controls 0.2 prreee . everee *. *Age 21 years +The mean value for 50 normal young American men, using the technique employed in the present study was 257,000 s seas foe oo Table 4.10 . vob gay see oe se neers pyrene gor, wee