Numbers fn Groups
Adequacy of Controls
.
eo
CHARACTERISTIC SOF
AVAILABLE DATA ON THE HEMATOLOGICAL
EFFECTS OF PENETRATING RADIATION
Source of data
Characteristics
ee
see een
Bombings 48 47
Clinical
Laboratory
Radiotherapy®
Accident x
Large
Small
Poor
Small
Poor
Japanese
Fair
Large
Sanall
Small
Yes
Yes
Yos
None
None
Minimal
None
Yes
No
Yes
Yes
No
No
No
No
No
Yes
Gamma,
Hard x rays,
gamma
Gamma, neutrons,
Gamma, beta
Hard x rays,
Yes
Good
Techniques?
Chance of bias duc to
Large
Large
sampling
techniques
“Normal’’
Yes
individuals
Internal
None
contamination
Additional trauma
necessary
some
ncutrons
Poor
Single exposure
Dose r«te
Yes
Instantaneous
~Sr/min
Body region
Total body
Usually
partial body
Geometry
Depth dose curve
Sublethal &
lethal
Narrow beam
Moderate fal!
Sublcthal
Narrow beam
Variable
gamma
to skin
x rays, betas
Good
Usually no
Dosage estimation
Dosage Range
3
'
(burns etc.)
Type of radiation
Large
Very good
Good | Yer
You
Good
Fair
Species extrapolation
Large
Larie
Animals**
Good
No
Fair
Yeu
Counting
Serial Counts
Exposed
Marshallese
Poor
Fair
Goud
Yes
Yes
Yes
Instantaneous
Varying,
~10r/min
Sublethal
Sublethal &
lethal
Narrow bean
~5r/hr
Total body; Total body
beta to skin
Total and
partial body
Subicthal &
lethal
Narrow beam __
360° field
Rapid fall off
Essentially
off
Vartable ‘rapid
flat
fall off to
flat
*Same technicians for all counts; rigidly standardized techniques throughout etc.
Table 4.11 MEAN PERIPHERAL BLOOD COUNT VALUES
FOR SEVERAL CONTROL POPULATIONS (x 10%
8
‘
dati
ource of data
upanese
Japanese Kure,
1947-1948
Total White Count
9.9
9.6
7.4
7.0
7.8
9.7
Neutrophiles
5.5
5.0
4.4
4.3
4.1
4.8
Lymphocytes
2.9
0.6
0.6
2.8
2.5
0.3
0.4
2.1
3.1
4.1
Eosinophiles
0.9
1.0
0.2
0.2
0.3
0.5
Q.1
0.0
0.0
250f
0.0
238
0.1
308
Basophiles
Americans**?
Platelets
Americans®
Controls
Majuro
Determination
Monocytes
1948-19498
KwajAmerican
0.3
Controls
0.2
prreee
.
everee
*.
*Age 21 years
+The mean value for 50 normal young American men, using the technique employed in the present
study was 257,000
s
seas
foe
oo
Table 4.10
.
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see
oe
se
neers pyrene gor,
wee