For most typical radiological contamination situations involving the inhalation of
radioactive material, organ dose commitments are calculated using published inhalation dose conversion factors.
activity on

particles of

Inhalation dose conversion factors are available for

less than

10um in diameter; however, inhalation dose

conversion factors for large particles are not available in the published literature.
Accordingly, for the purpose of this dose calculation a set of large-particle inhalation
dose conversion factors is developed.
For particles greater than 10 um diameter, essentially all of the inhaled material

is initially deposited in the nasal or nasopharyngeal region of the respiratory tract
(Reference 17).

This material is removed by chemical (absorption) and mechanical

processes, and goes either to the blood, with subsequent transfer to other body organs,

or to the gastrointestinal (GI) tract, with subsequent transfer to the blood and further
transfer to other body organs or bodily elimination by excretion.

The "pulmonary

clearance classification" of the inhaled material (roughly analogous to the solubility of
the material) determines the amount of the material that is initially transferred to the

blood or the GI tract; for example, 99 percent of an "insoluble" material will go to the
the GI tract with only | percent going to the blood, whereas a "very soluble" material
will be divided evenly between the GI tract and the blood (Reference 16).

As ingestion plays a major role. in the fate of an inhaled large particle, the largeparticle inhalation dose conversion factors used for the present dose calculation are
obtained by modifying ingestion dose conversion factors.

This modification is

necessary to properly account for that portion of the inhaled material that is initially
transferred to the blood, rather than to the GI tract.

The metabolic data needed to

construct . ‘halation/ingestion dose conversion factors are given in ORNL/NUREG/
TM-190 (Reference 16) for the most radiologically significant radionuclides.

The

TM-190 dose conversion factors, based on the most current dosimetry information, are
used in conjunction with these.

unmodified

ingestion

dose

For those radionuclides not addressed in TM-190,

conversion

factors

(Reference 18).

21

are

taken

from

NUREG-0172

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