-_ eenanel under trade names; Permakleer 80 and Permakleer SP; but from the information we have obtained from the manufacturer we gather the composition of Pk 80 is: HOCH,—CHp | H000H HoH N-C-CoN Hooe-ci,, \cu,co0H We do not know the structure of Pk SP. In a preliminary toxicity study in mice we found the LDZ5 for a single intraperitoneal dose was approximately 400 mg/kg. The material was tested for its ability to effect excretion of Pu in the usual fashion in rats. rats were given 320 ms/kg/d. In the first pilot study the experimental ~ The animals given Pk 80 died in 2 or 3 days and the animals given Pk SP in 3-4 days, The study was set up again using 80 mg/kg/d. All the animals survived the experiment. . : : The Pu was given I.V. and. the medica- Classtfication changed tion I.P. twice daily. to The resyt Gms places sq ih ret at; - Per TABLE I CXLéy Lio (Person acthorizing chanje £a_classification} (Date) RESULTS QP Rx OF Pu BEARING ANIMELS/Z AL. LD (Signaturo of person nakitg the charg, and date) Pk 80* Day 1. Urine . 4 Total Oral 53 7.40 1.88 10 96 »38 -17 2.80 260 11.76 Carcass 4.15 3.19 Liver 7.34 44.60 * - 3 TP. 05 85 Skeleton COPEOOok 2 Controls Pk SP* «69 228 3.23 LP. Oral 7.2 1.06 3.0 1.2 38 ~34 0.71 12,11 220 1.98 4.0 2.3 3.0 5.8 7.12 5.45 8.76 41.39 41.40 38.75 36.30 Results expressed in & of injected dose. *a a wy 3 1A